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Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e01353-18. doi: 10.1128/AAC.01353-18. Print 2018 Dec.

Rifampin Resistance in Staphylococci after Rifaximin Intake for Surgical Prophylaxis in Elective Colorectal Surgery.

Author information

1
Microbiology Laboratory, CATLAB, Viladecavalls, Spain epadilla@catlab.cat.
2
Surgery Service, Hospital de Terrassa (Consorci Sanitari de Terrassa), Terrassa, Spain.
3
Infectious Diseases Unit, Hospital de Terrassa (Consorci Sanitari de Terrassa), Terrassa, Spain.
4
Infection Control Team, Infectious Diseases Unit, Hospital de Terrassa (Consorci Sanitari de Terrassa), Terrassa, Spain.
5
Microbiology Laboratory, CATLAB, Viladecavalls, Spain.

Abstract

The aim of our study was to determine whether rifampin resistance emerges in human skin staphylococci after oral intake of rifaximin for surgical prophylaxis. Rifampin-resistant staphylococci appeared on the skin of 32 out of 74 patients (43.2%) two weeks after prophylactic treatment with rifaximin. In all cases, the resistant strains were coagulase-negative staphylococci. The resistance completely reverted after three months. This study shows the emergence of transient resistance to rifampin after rifaximin intake.

KEYWORDS:

Staphylococcus ; antibiotic resistance; rifampin; rifaximin; surgical prophylaxis

PMID:
30249689
PMCID:
PMC6256800
[Available on 2019-05-26]
DOI:
10.1128/AAC.01353-18

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