Format

Send to

Choose Destination
Diagn Microbiol Infect Dis. 2019 Feb;93(2):89-91. doi: 10.1016/j.diagmicrobio.2018.08.013. Epub 2018 Sep 1.

Prevalence of Haemophilus influenzae with alteration of PBP 3 sequence over a 1-year period in a French hospital: focus on a clinical failure after ceftriaxone treatment.

Author information

1
CHU Nantes, Service de Bactériologie-Hygiène, 9 quai Moncousu, Nantes Cedex 1, F-44093, France.
2
CHU Nantes, Institut du Thorax, Service de Pneumologie, boulevard Jacques-Monod, Saint-Herblain, Nantes Cedex 1, F-44093, France.
3
CHU Nantes, Service de Bactériologie-Hygiène, 9 quai Moncousu, Nantes Cedex 1, F-44093, France. Electronic address: stephane.corvec@chu-nantes.fr.

Abstract

Among 547 Haemophilus influenzae isolates recovered in our center, 45 displayed a phenotype of loss of PBP 3 affinity (8.2%). Two isolates with 6 substitutions in PBP 3 showed decreased susceptibility to third-generation cephalosporins. Clinical data revealed clinical failure after ceftriaxone treatment in a context of bronchitis in a patient with pulmonary sarcoidosis.

KEYWORDS:

Haemophilus influenzae; PBP 3; Resistance; Third-generation cephalosporin

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center