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Nutrients. 2018 Sep 22;10(10). pii: E1360. doi: 10.3390/nu10101360.

The Synergistic Effects of Resveratrol combined with Resistant Training on Exercise Performance and Physiological Adaption.

Author information

1
Center for General Education, Taipei Medical University, Taipei 11031, Taiwan. kevinkan@tmu.edu.tw.
2
Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan. 1061304@ntsu.edu.tw.
3
Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei City 11031, Taiwan. f91625059@tmu.edu.tw.
4
Nutrition Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan. f91625059@tmu.edu.tw.
5
Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan. chiu2295@yahoo.com.tw.
6
Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan. john5523@ntsu.edu.tw.
7
Department of Exercise and Health Science, National Taipei University of Nursing and Health Sciences, Taipei 11219, Taiwan. wenching@ntunhs.edu.tw.

Abstract

The comprehensive studies done on resveratrol (RES) support that this polyphenol has multiple bioactivities and is widely accepted for dietary supplementation. Furthermore, regular exercise is known to have benefits on health and is considered as a form of preventive medicine. Although the vast majority of prior studies emphasize the efficacy of aerobic exercise in promoting physiological adaptions, other types of exercise, such as resistance exercise and high-intensity interval training (HIIT), may achieve similar or different physiological outcomes. Few studies have looked into the effectiveness of a combinational, synergistic approach to exercise using a weight-loading ladder climbing animal platform. In this study, ICR mice were allocated randomly to the RES and training groups using a two-way ANOVA (RES × Training) design. Exercise capacities, including grip strength, aerobic performance, and anaerobic performance, were assessed and the physiological adaptions were evaluated using fatigue-associated indexes that were implemented immediately after the exercise intervention. In addition, glycogen levels, muscular characteristics, and safety issues, including body composition, histopathology, and biochemistry, were further elucidated. Synergistic effects were observed on grip strength, anaerobic capacities, and exercise lactate, with significant interaction effects. Moreover, the training or RES may have contributed significantly to elevating aerobic capacity, tissue glycogen, and muscle hypertrophy. Toxic and other deleterious effects were also considered to evaluate the safety of the intervention. Resistance exercise in combination with resveratrol supplementation may be applied in the general population to achieve better physiological benefits, promote overall health, and promote participation in regular physical activities.

KEYWORDS:

hypertrophy; performance; physiological adaption; resistance exercise; resveratrol

PMID:
30249003
PMCID:
PMC6212981
DOI:
10.3390/nu10101360
[Indexed for MEDLINE]
Free PMC Article

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