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J Clin Med. 2018 Sep 21;7(10). pii: E297. doi: 10.3390/jcm7100297.

Effects of the Hormone Replacement Therapy and of Soy Isoflavones on Bone Resorption in Postmenopause.

Author information

1
Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania. mirela_tit@yahoo.com.
2
Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania. simonabungau@gmail.com.
3
Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania. dr.iovan@biostandard.ro.
4
Department of Psycho Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania. delia_cseppento@yahoo.com.
5
Department of Psycho Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania. laura_endres@yahoo.com.
6
Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania. cristian.sava2004@gmail.com.
7
Department of Physical Education, Sport and Physical Therapy, Faculty of Geography, Tourism and Sport, University of Oradea, 410087 Oradea, Romania. sabauancamaria@yahoo.com.
8
Department of Obstetrics and Gynecology, Arad County Clinical Hospital, 310048 Arad, Romania. gfurau@yahoo.com.
9
"Vasile Goldis" Western University of Arad, 310045 Arad, Romania. gfurau@yahoo.com.
10
Department of Obstetrics and Gynecology, Arad County Clinical Hospital, 310048 Arad, Romania. cristianfurau@gmail.com.
11
"Vasile Goldis" Western University of Arad, 310045 Arad, Romania. cristianfurau@gmail.com.

Abstract

Postmenopausal osteoporosis is the most common form of osteoporosis and one of the major public health problems in developed countries. The prevalence of this condition, associated with the physiological stage of menopause, is continuously increasing. This study evaluated the effectiveness of soy isoflavones as compared to hormone replacement therapy (HRT) in low doses, on the prevention of postmenopausal osteoporosis, by determining bone mineral density (BMD) and urinary deoxypyridinoline (D-pyr) in physiological postmenopausal women. The study was conducted over a period of 12 months, on three parallel groups, which included a total of 325 postmenopausal women (HRT group: n = 95; phytoestrogens group: n = 124; control group: n = 106). At the one-year evaluation, we observed T-score normalization in a small number of cases (5.26%, 2.42% and 0.00%, respectively). The average values of D-Pyr decreased by 11.38% in the group treated with phytoestrogens (p < 0.05) and by 15.32% in the group that followed HRT (p < 0.05); it increased by 4.38% in the control group (p > 0.05). Both therapies have beneficial effects on bone metabolism, leading to a significant decrease in the evolution of bone resorption and there are no major differences between the efficacy of HRT and phytoestrogens in terms of the effects on BMD and bone resorption.

KEYWORDS:

BMD; HRT; bone resorption; deoxypyridinoline; phytoestrogens

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