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Maturitas. 2018 Oct;116:54-58. doi: 10.1016/j.maturitas.2018.07.011. Epub 2018 Jul 19.

A panel of multibiomarkers of inflammation, fibrosis, and catabolism is normal in healthy centenarians but has high values in young patients with myocardial infarction.

Author information

1
Servicio de Cardiología, Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, CIBERCV, Madrid, Spain.
2
Universidad Complutense, Madrid, Spain.
3
Servei de Cardiologia, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
4
Universidad Europea and Research Institute Hospital 12 de Octubre ('i+12)', Madrid, Spain.
5
2E Science, Robbio, Pavia, Italy.
6
Institut del Cor, Hospital Universitari Germans Trias i Pujol, UAB, Barcelona, Spain.
7
Servicio de Cardiología, Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, CIBERCV, Madrid, Spain; Universidad Complutense, Madrid, Spain.
8
Servicio de Cardiología, Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, CIBERCV, Madrid, Spain; Universidad Complutense, Madrid, Spain; Universidad Europea, Madrid. Electronic address: mmselles@secardiologia.es.

Abstract

OBJECTIVES:

Frailty confers a poor prognosis as it portends an increased risk of disability, dependence, and mortality. Although frailty is generally associated with aging, a marked interindividual variability exists. We compared a range of serum biomarkers of inflammation, fibrosis, and catabolism in three distinct cohorts, consisting of young patients with myocardial infarction, age-matched healthy volunteers, and disease-free centenarians.

STUDY DESIGN:

Prospective observational registry study.

MAIN OUTCOME MEASURES:

Serum levels of five biomarkers were measured in the three study groups.

RESULTS:

Disease-free centenarians had significantly lower (all p < 0.01) serum biomarker levels than young patients with myocardial infarction (growth differentiation factor 15: 877 ± 299 vs. 1062 ± 358 pg/mL; matrix metalloproteinase (MMP)-1: 1.7 ± 0.9 vs. 3.2 ± 1.2 ng/mL; MMP-2 174 ± 38 vs. 214 ± 44 ng/mL; MMP-9 325 ± 73 vs. 407 ± 54 ng/mL; and carboxy-terminal telopeptide of collagen type I: 3.3 ± 1 vs. 4.2 ± 1.3 ng/mL). No significant differences in biomarker concentrations between healthy controls and centenarians were identified.

CONCLUSIONS:

Disease-free centenarians had significantly lower levels of inflammation, fibrosis, and catabolism biomarkers than young patients with myocardial infarction. Advanced aging per se is not invariably associated with these biomarkers.

KEYWORDS:

Aging; Biomarkers; Cardiovascular risk; Centenarians; Frailty

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