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Thorax. 2019 Mar;74(3):309-312. doi: 10.1136/thoraxjnl-2018-211897. Epub 2018 Sep 22.

Sputum exosomes: promising biomarkers for idiopathic pulmonary fibrosis.

Author information

1
Laboratory of Molecular Angiogenesis, GIGA-R, University of Liège, Liège, Belgium.
2
Pneumology Department, CHU Liège, Liège, Belgium.
3
Laboratory of Pneumology, GIGA-I3, University of Liège, Liège, Belgium.
4
Laboratoire de Biologie Cellulaire et Tissulaire, GIGA-R, University of Liège, Liège, Belgium.
5
Laboratoire de Signalisation et Interactions des Protéines, GIGA-R, University of Liège, Liège, Belgium.
#
Contributed equally

Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease of unknown aetiology which leads rapidly to death. As diagnosis of IPF is complex, we aimed to characterise microRNA (miRNA) content of exosomes from sputum of patients with IPF. Using miRNA quantitative PCR array, we found a substantial dysregulation of sputum exosomal miRNA levels between patients with IPF and healthy subjects and identified a unique signature of three miRNAs. Interestingly, we found a negative correlation between miR-142-3p and diffusing capacity of the lungs for carbon monoxide/alveolar volume. This is the first characterisation of miRNA content of sputum-derived exosomes in IPF that identified promising biomarkers for diagnosis and disease severity.

KEYWORDS:

idiopathic pulmonary fibrosis; interstitial fibrosis

PMID:
30244194
PMCID:
PMC6467246
DOI:
10.1136/thoraxjnl-2018-211897
[Indexed for MEDLINE]
Free PMC Article

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