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Sci Rep. 2018 Sep 21;8(1):14182. doi: 10.1038/s41598-018-32499-8.

Steeper structure-function relationship in eyes with than without a parapapillary deep-layer microvasculature dropout.

Author information

1
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
2
Department of Applied Statistics, Yonsei University, Seoul, Republic of Korea.
3
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. twkim7@snu.ac.kr.

Abstract

The degree of visual field (VF) loss can vary widely at a given level of retinal nerve fiber layer (RNFL) thickness. The cause of this variability is not fully understood. This cross-sectional study investigated whether the presence of choroidal microvasculature dropout (MvD) influences on the structure-function relationship among glaucomatous eyes. Seventy-one primary open-angle glaucoma (POAG) patients with choroidal MvD as determined by optical coherence tomography angiography (MvD+ group), and 71 age- and inferotemporal (IT) RNFL thickness-matched POAG patients without MvD (MvD- group) were included. VF sensitivity within the region corresponding to the IT RNFL sector was averaged using the total and pattern deviation fields. The slope of log-scale RNFL thickness versus VF defect was significantly steeper for the MvD+ than the MvD- group, as determined by both total and pattern deviation maps (P = 0.004 and <0.001, respectively). Both total and pattern VF deviation were significantly worse in the MvD+ than in the MvD- group (P = 0.002 and 0.007, respectively). Same results were obtained in subgroup analyses for eyes with thick and thin RNFL thickness (all P ≤ 0.027). These data suggest that parapapillary MvD is associated with poorer function of the remaining axons in eyes with POAG.

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