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Sci Rep. 2018 Sep 21;8(1):14181. doi: 10.1038/s41598-018-31530-2.

Dvl3 polymorphism interacts with life events and pro-inflammatory cytokines to influence major depressive disorder susceptibility.

Author information

1
Psychology Department of the Public Health Institute of Harbin Medical University, Heilongjiang Province, Harbin, China.
2
Affiliated Hosptial of Jining Medical University, Shandong Province, Jining, China.
3
Medical Psychological Institute of the Second Xiangya Hospital of Central South University, Hunan Province, Changsha, China.
4
Psychology Department of the Public Health Institute of Harbin Medical University, Heilongjiang Province, Harbin, China. yanjie1965@163.com.
5
Harbin Medical University, Heilongjiang Province, Harbin, China. caodp211@163.com.
6
Psychology Department of the Public Health Institute of Harbin Medical University, Heilongjiang Province, Harbin, China. qiuxiaohui@foxmail.com.

Abstract

The purpose of this study is to explore Dvl3 variants and their interaction with negative life events on MDD susceptibility in a Chinese Han population. Additionally, we also attempted to identify whether there is an association between Dvl3 variants and pro-inflammatory cytokines. A total of 1102 participants, consisting of 550 patients with MDD and 552 healthy subjects, were recruited for genotyping by TaqMan allelic discrimination assay. Pro-inflammatory cytokine mRNA levels in peripheral blood were measured by QPCR. After the assessment of negative life events by the Life Events Scale, the Dvl3 gene-environment interaction (G × E) and risk factors were evaluated using generalized multifactor dimensionality reduction method (GMDR) and logistic regression analysis, respectively. This study is the first to reveal the interaction between Dvl3 allelic variations and negative life events as well as pro-inflammatory cytokines on MDD susceptibility in a Chinese Han population.

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