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Biochem Soc Trans. 2018 Oct 19;46(5):1073-1082. doi: 10.1042/BST20180112. Epub 2018 Sep 20.

Extracellular vesicles: translational challenges and opportunities.

Author information

1
Academic Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, S10 2TA Sheffield, U.K. hsclemmens1@sheffield.ac.uk.
2
Academic Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, S10 2TA Sheffield, U.K.
3
Sheffield Institute for Nucleic Acids, University of Sheffield, S10 2TA Sheffield, U.K.

Abstract

Extracellular vesicles (EVs) are a heterogeneous group of small lipid-enclosed structures with myriad roles in physiology and disease. The recent surge of interest in EVs has led to greater understanding of their biology and appreciation of how they might be utilised as diagnostic and therapeutic tools. There remain, however, a number of challenges that must be overcome before EVs may be used routinely in the clinic. In this review we will discuss the translational potential of EVs and the current technologies available to isolate, purify and analyse EVs and their contents.

KEYWORDS:

RNA; biomarkers; exosome; extracellular vesicle; microvesicle; translation

PMID:
30242120
DOI:
10.1042/BST20180112
[Indexed for MEDLINE]

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