Format

Send to

Choose Destination
Biosci Rep. 2018 Oct 31;38(5). pii: BSR20181043. doi: 10.1042/BSR20181043. Print 2018 Oct 31.

Bakuchiol protects against pathological cardiac hypertrophy by blocking NF-κB signaling pathway.

Author information

1
Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
2
Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China zhaoluosha2018@sina.com.

Abstract

Bakuchiol (Bak), a monoterpene phenol isolated from the seeds of Psoralea corylifolia, has been widely used to treat a large variety of diseases in both Indian and Chinese folkloric medicine. However, the effects of Bak on cardiac hypertrophy remain unclear. Therefore, the present study was designed to determine whether Bak could alleviate cardiac hypertrophy. Mice were subjected to aortic banding (AB) to induce cardiac hypertrophy model. Bak of 1 ml/100 g body weight was given by oral gavage once a day from 1 to 8 weeks after surgery. Our data demonstrated for the first time that Bak could attenuate pressure overload-induced cardiac hypertrophy and could attenuate fibrosis and the inflammatory response induced by AB. The results further revealed that the effect of Bak on cardiac hypertrophy was mediated by blocking the activation of the NF-κB signaling pathway. In vitro studies performed in neonatal rat cardiomyocytes further proved that the protective effect of Bak on cardiac hypertrophy is largely dependent on the NF-κB pathway. Based on our results, Bak shows profound potential for its application in the treatment of pathological cardiac hypertrophy, and we believe that Bak may be a promising therapeutic candidate to treat cardiac hypertrophy and heart failure.

KEYWORDS:

Bakuchiol; NF kappa B; aortic banding; cardiac hypertrophy; cardiomyocytes

PMID:
30242058
PMCID:
PMC6209581
DOI:
10.1042/BSR20181043
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center