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Nutrients. 2018 Sep 21;10(10). pii: E1348. doi: 10.3390/nu10101348.

Effect of A Very Low-Calorie Ketogenic Diet on Food and Alcohol Cravings, Physical and Sexual Activity, Sleep Disturbances, and Quality of Life in Obese Patients.

Author information

1
Division of Endocrinology, Department of Medicine, Molecular and Cellular Endocrinology Area, Complejo Hospitalario Universitario de Santiago (CHUS), Instituto de Investigación Sanitaria de Santiago (IDIS), and Santiago de Compostela University (USC), Santiago de Compostela 15706, Spain. anaisabel0121@gmail.com.
2
CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, Madrid 28029, Spain. anaisabel0121@gmail.com.
3
Division of Endocrinology, Department of Medicine, Molecular and Cellular Endocrinology Area, Complejo Hospitalario Universitario de Santiago (CHUS), Instituto de Investigación Sanitaria de Santiago (IDIS), and Santiago de Compostela University (USC), Santiago de Compostela 15706, Spain. diedgomez@gmail.com.
4
Faculty of Health Sciences, University of Santander (UDES), Bucaramanga 680003, Colombia. diedgomez@gmail.com.
5
Division of Endocrinology, Department of Medicine, Molecular and Cellular Endocrinology Area, Complejo Hospitalario Universitario de Santiago (CHUS), Instituto de Investigación Sanitaria de Santiago (IDIS), and Santiago de Compostela University (USC), Santiago de Compostela 15706, Spain. anabelecrujeiras@hotmail.com.
6
CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, Madrid 28029, Spain. anabelecrujeiras@hotmail.com.
7
CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, Madrid 28029, Spain. Roser.Granero@uab.cat.
8
Department of Psychobiology and Methodology, Autonomous University of Barcelona, Barcelona 08193, Spain. Roser.Granero@uab.cat.
9
CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, Madrid 28029, Spain. zaguera@bellvitgehospital.cat.
10
Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Barcelona 08908, Spain. zaguera@bellvitgehospital.cat.
11
CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, Madrid 28029, Spain. sjimenez@bellvitgehospital.cat.
12
Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Barcelona 08908, Spain. sjimenez@bellvitgehospital.cat.
13
Medical Department Pronokal, Pronokal Group, Barcelona 08009, Spain. Ignacio.S@pronokal.com.
14
Center for Research in Metabolic Syndrome, Prediabetes and Diabetes, Fundacion Oftalmologica de Santander (FOSCAL), Floridablanca 681004, Colombia. jplopezj@gmail.com.
15
CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, Madrid 28029, Spain. ffernandez@bellvitgehospital.cat.
16
Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Barcelona 08908, Spain. ffernandez@bellvitgehospital.cat.
17
Division of Endocrinology, Department of Medicine, Molecular and Cellular Endocrinology Area, Complejo Hospitalario Universitario de Santiago (CHUS), Instituto de Investigación Sanitaria de Santiago (IDIS), and Santiago de Compostela University (USC), Santiago de Compostela 15706, Spain. endocrine@usc.es.
18
CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, Madrid 28029, Spain. endocrine@usc.es.

Abstract

Psychological well-being and hunger and food control are two relevant factors involved in the success of weight-loss therapy in treating obesity. Thus, this study aims to evaluate food and alcohol cravings, physical and sexual activity, sleep, and life quality (QoL) in obese patients following a very low-calorie ketogenic (VLCK) diet, as well as the role of weight lost and ketosis on these parameters. A battery of psychological test was performed in twenty obese patients (12 females, 47.2 ± 10.2 year and BMI of 35.5 ± 4.4) through the course of a 4-month VLCK diet on four subsequent visits: baseline, maximum ketosis, reduced ketosis, and endpoint. Each subject acted as their own control. Relevantly, the dietary-induced changes in body composition (7.7 units of BMI lost, 18 kg of fat mass (1.2 kg of visceral fat mass)) were associated with a statistically significant improvement in food craving scores, physical activity, sleepiness, and female sexual function. Overall, these results also translated in a notable enhancement in QoL of the treated obese patients. Therefore, the rapid and sustained weight and fat mass (FM) loss induced by the VLCK diet is associated with good food control and improvements in the psychological well-being parameters in obese subjects, which could contribute to the long-term success of this therapy.

KEYWORDS:

PNK method; QoL; food addition; ketogenic diet; obesity; protein diet; sexual function; sleep quality; very low-energy diet

PMID:
30241426
PMCID:
PMC6213862
DOI:
10.3390/nu10101348
[Indexed for MEDLINE]
Free PMC Article

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