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Nanomedicine. 2019 Jan;15(1):37-46. doi: 10.1016/j.nano.2018.09.001. Epub 2018 Sep 19.

Unmodified hydrated С60 fullerene molecules exhibit antioxidant properties, prevent damage to DNA and proteins induced by reactive oxygen species and protect mice against injuries caused by radiation-induced oxidative stress.

Author information

1
Lobachevsky State University of Nizhni Novgorod, Nizhny Novgorod, Russian Federation; Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russian Federation; Moscow Regional Research and Clinical Institute (MONIKI), Moscow, Russian Federation. Electronic address: s_makariy@rambler.ru.
2
Lobachevsky State University of Nizhni Novgorod, Nizhny Novgorod, Russian Federation.
3
Institute of Cell Biophysics of the Russian Academy of Sciences, Pushchino, Moscow Region, Russian Federation.
4
Bauman Moscow State Technical University, Moscow, Russian Federation.
5
Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russian Federation; National Research Nuclear University MEPhI, Moscow, Russian Federation.
6
Moscow Regional Research and Clinical Institute (MONIKI), Moscow, Russian Federation.
7
All-Russian Research Institute of Phytopathology, Moscow Region, Russian Federation.
8
Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences, Moscow, Russian Federation.
9
Mari State University, Yoshkar-Ola, Mari El, Russian Federation; Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Pushchino, Moscow Region, Russian Federation.
10
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Pushchino, Moscow Region, Russian Federation.
11
Lobachevsky State University of Nizhni Novgorod, Nizhny Novgorod, Russian Federation; Sechenov University, Moscow, Russian Federation; ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP), Department of Physics & Astronomy, Macquarie University, Sydney, NSW, Australia.

Abstract

Unmodified hydrated С60 fullerene molecules (C60UHFM) were shown to reduce the formation ROS in water and 8-oxoguanine in DNA upon ionizing radiation impact. C60UHFM efficiently eliminate long-lived protein radicals arising after irradiation. In irradiated mice C60UHFM reduce the rate of single/double-strand DNA breaks and amount of chromosomal breaks. The radioprotective activity of C60UHFM was estimated by the survival rate of animals; the dose modification factor for animal survival was 1.3. Hematological tests showed that C60UHFM injection in mice prior to irradiation results in a decrement of irradiation-induced leucopenia and thrombocytopenia. Histological analysis testified that C60UHFM provide significant protection of small intestine tissues in mice against irradiation-induced damage. The obtained data assume that the radioprotective properties of C60UHFM are determined by their antioxidant, antiradical and DNA-protective qualities. Thus, it was demonstrated that C60UHFM are a novel antioxidant and radioprotective agent capable of substantial reduction of the harmful effects of ionizing radiation.

KEYWORDS:

DNA damage; Fullerene C(60); Nanostuctures; Radioprotectors; Reactive oxygen species; X-rays

PMID:
30240826
DOI:
10.1016/j.nano.2018.09.001
[Indexed for MEDLINE]

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