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Int Wound J. 2019 Feb;16(1):134-138. doi: 10.1111/iwj.13003. Epub 2018 Sep 21.

Beyond 2D: 3D bioprinting for skin regeneration.

Wang R1,2, Wang Y1,2, Yao B2,3, Hu T2,3, Li Z4, Huang S2,4, Fu X2,4.

Author information

1
Tianjin Medical University, Tianjin, China.
2
Key Laboratory of Tissue Repair and Regeneration of PLA, and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, First Hospital Affiliated to General Hospital of PLA, Beijing, China.
3
School of Medicine, Nankai University, Tianjin, China.
4
Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Sciences, General Hospital of PLA, Beijing, China.

Abstract

Essential cellular functions that are present in tissues are missed by two-dimensional (2D) cell monolayer culture. It certainly limits their potential to predict the cellular responses of real organisms. Engineering approaches offer solutions to overcome current limitations. For example, establishing a three-dimensional (3D)-based matrix is motivated by the need to mimic the functions of living tissues, which will have a strong impact on regenerative medicine. However, as a novel approach, it requires the development of new standard protocols to increase the efficiency of clinical translation. In this review, we summarised the various aspects of requirements related to well-suited 3D bioprinting techniques for skin regeneration and discussed how to overcome current bottlenecks and propel these therapies into the clinic.

KEYWORDS:

3D bioprinting; extracellular matrices; skin regeneration

PMID:
30240111
DOI:
10.1111/iwj.13003

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