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Schizophr Bull. 2019 Jan 1;45(1):7-16. doi: 10.1093/schbul/sby127.

Extracellular Vesicles for Research on Psychiatric Disorders.

Author information

1
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD.

Abstract

Extracellular vesicles (EVs) have gained increasing attention as underexplored intercellular communication mechanisms in basic science and as potential diagnostic tools in translational studies, particularly those related to cancers and neurological disorders. This article summarizes accumulated findings in the basic biology of EVs, EV research methodology, and the roles of EVs in brain cell function and dysfunction, as well as emerging EV studies in human brain disorders. Further research on EVs in neurobiology and psychiatry may open the door to a better understanding of intercellular communications in healthy and diseased brains, and the discovery of novel biomarkers and new therapeutic strategies in psychiatric disorders.

PMID:
30239909
PMCID:
PMC6293232
[Available on 2020-01-01]
DOI:
10.1093/schbul/sby127

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