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J Infect Dis. 2019 Jan 29;219(4):619-623. doi: 10.1093/infdis/jiy551.

Azithromycin Susceptibility Among Neisseria gonorrhoeae Isolates and Seasonal Macrolide Use.

Author information

1
Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
2
Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
3
Center for Communicable Disease Dynamics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
4
Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Abstract

Rising azithromycin nonsusceptibility among Neisseria gonorrhoeae isolates threatens current treatment recommendations, but the cause of this rise is not well understood. We performed an ecological study of seasonal patterns in macrolide use and azithromycin resistance in N. gonorrhoeae, finding that population-wide macrolide use is associated with increased azithromycin nonsusceptibility. These results, indicative of bystander selection, have implications for antibiotic prescribing guidelines.

PMID:
30239814
PMCID:
PMC6350947
[Available on 2020-01-29]
DOI:
10.1093/infdis/jiy551

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