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Curr Opin Anaesthesiol. 2018 Dec;31(6):749-755. doi: 10.1097/ACO.0000000000000660.

Genetics of perioperative pain management.

Author information

1
Department of Anesthesia, Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana, USA.

Abstract

PURPOSE OF REVIEW:

The current review will discuss the current literature on genetics of pain and analgesia, with special emphasis on perioperative setting. We will also discuss pharmacogenetics-based management guidelines, current clinical status and future perspectives.

RECENT FINDINGS:

Recent literature suggests that the interindividual variability in pain and postoperative analgesic response is at least in part because of one's genetic make-up. Some of the well characterized polymorphisms that are associated with surgical pain and opioid-related postoperative adverse outcomes are described in catechol-O-methyl transferase, CYP2D6 and μ-opioid receptor (OPRM1), ATP-binding cassette subfamily B member 1, ABCC3, organic cation transporter 1 genes. Clinical Pharmacogenetics Implementation Consortium has put forth recommendations on CYP2D6 genotype-based opioid selection and dosing. The list of drug-gene pairs studied continue to expand.

SUMMARY:

Pharmacogenetic approach marks the dawn of personalized pain medicine both in perioperative and chronic pain settings.

PMID:
30239351
DOI:
10.1097/ACO.0000000000000660
[Indexed for MEDLINE]

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