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Sci Rep. 2018 Sep 20;8(1):14096. doi: 10.1038/s41598-018-32337-x.

The effect of serum triglyceride concentration on the outcome of acute pancreatitis: systematic review and meta-analysis.

Author information

1
Department of Pathophysiology, University of Szeged, Szeged, Hungary.
2
Institute for Translational Medicine and Szentagothai Research Center, Medical School, University of Pécs, Pécs, Hungary.
3
MTASZTE Translational Gastroenterology Research Group, University of Szeged, Szeged, Hungary.
4
First Department of Medicine, University of Szeged, Szeged, Hungary.
5
Department of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary.
6
Department of Cardiology and Angiology, First Department of Medicine and Szentagothai Research Center, Medical School, University of Pécs, Pécs, Hungary.
7
Department of Haematology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary.
8
Department of Public Health Medicine, Medical School, University of Pécs, Pécs, Hungary.
9
Department of Radiology, Medical School, University of Pécs, Pécs, Hungary.
10
Department of Pathophysiology, University of Szeged, Szeged, Hungary. rakonczay.zoltan@med.u-szeged.hu.

Abstract

Elevated serum triglyceride concentration (seTG, >1.7 mM or >150 mg/dL) or in other words hypertriglyceridemia (HTG) is common in the populations of developed countries. This condition is accompanied by an increased risk for various diseases, such as acute pancreatitis (AP). It has been proposed that HTG could also worsen the course of AP. Therefore, in this meta-analysis, we aimed to compare the effects of various seTGs on the severity, mortality, local and systemic complications of AP, and on intensive care unit admission. 16 eligible studies, including 11,965 patients were retrieved from PubMed and Embase. The results showed that HTG significantly elevated the odds ratio (OR = 1.72) for severe AP when compared to patients with normal seTG (<1.7 mM). Furthermore, a significantly higher occurrence of pancreatic necrosis, persistent organ failure and renal failure was observed in groups with HTG. The rates of complications and mortality for AP were significantly increased in patients with seTG >5.6 mM or >11.3 mM versus <5.6 mM or <11.3 mM, respectively. We conclude that the presence of HTG worsens the course and outcome of AP, but we found no significant difference in AP severity based on the extent of HTG.

PMID:
30237456
DOI:
10.1038/s41598-018-32337-x
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