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Science. 2018 Sep 21;361(6408). pii: eaat5236. doi: 10.1126/science.aat5236.

A gut-brain neural circuit for nutrient sensory transduction.

Author information

1
Department of Medicine, Duke University, Durham, NC, USA.
2
School of Medicine, Duke University, Durham, USA, NC.
3
Department of Biomedical Engineering, Duke University, Durham, NC, USA.
4
Department of Medicine, Duke University, Durham, NC, USA. diego.bohorquez@duke.edu.
5
Department of Neurobiology, Duke University, Durham, NC, USA.
6
Duke Institute for Brain Sciences, Duke University, Durham, NC, USA.

Abstract

The brain is thought to sense gut stimuli only via the passive release of hormones. This is because no connection has been described between the vagus and the putative gut epithelial sensor cell-the enteroendocrine cell. However, these electrically excitable cells contain several features of epithelial transducers. Using a mouse model, we found that enteroendocrine cells synapse with vagal neurons to transduce gut luminal signals in milliseconds by using glutamate as a neurotransmitter. These synaptically connected enteroendocrine cells are referred to henceforth as neuropod cells. The neuroepithelial circuit they form connects the intestinal lumen to the brainstem in one synapse, opening a physical conduit for the brain to sense gut stimuli with the temporal precision and topographical resolution of a synapse.

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PMID:
30237325
DOI:
10.1126/science.aat5236
[Indexed for MEDLINE]

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