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J Am Acad Dermatol. 2019 May;80(5):1215-1231.e6. doi: 10.1016/j.jaad.2018.03.063. Epub 2018 Sep 17.

Acquired disorders with depigmentation: A systematic approach to vitiliginoid conditions.

Author information

1
Department of Internal Medicine, University of Florida College of Medicine and University of Florida Health, Gainesville, Florida. Electronic address: msaleem@g.clemson.edu.
2
McGill University, Montreal, Quebec, Canada.
3
Department of Dermatology and Pediatrics, University of Florida, Gainesville, Florida.
4
Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.
5
Department of Dermatology and Pediatric Dermatology, Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatologic Institute, IRCCS, Rome, Italy.

Abstract

Acquired disorders with depigmentation are commonly encountered by dermatologists and present with a wide differential diagnosis. Vitiligo, the most common disorder of acquired depigmentation, is characterized by well-defined depigmented macules and patches. Other conditions, such as chemical leukoderma, can present with similar findings, and are often easily mistaken for vitiligo. Key clinical features can help differentiate between acquired disorders of depigmentation. The first article in this continuing medical education series focuses on conditions with a vitiligo-like phenotype. Early recognition and adequate treatment of these conditions is critical in providing appropriate prognostication and treatment.

KEYWORDS:

Alezzandrini syndrome; Vogt-Koyanagi-Harada; chemical leukoderma; extramammary Paget disease; halo nevi; lichen sclerosus; melanoma-associated leukoderma; onchocerciasis; pinta; scleroderma leukoderma

PMID:
30236516
DOI:
10.1016/j.jaad.2018.03.063
[Indexed for MEDLINE]

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