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Neuron. 2018 Sep 19;99(6):1102-1104. doi: 10.1016/j.neuron.2018.09.006.

Peripheral Kappa Opioid Receptor Signaling Takes on a Central Role.

Author information

1
Pharmacology Institute, Medical Faculty Heidelberg, Heidelberg University, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany. Electronic address: paul.naser@pharma.uni-heidelberg.de.
2
Pharmacology Institute, Medical Faculty Heidelberg, Heidelberg University, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany. Electronic address: rohini.kuner@pharma.uni-heidelberg.de.

Abstract

With the current unmet demand for effective analgesics and the opioid crisis, pain relief without major central adverse effects is highly appealing. In this issue of Neuron, Snyder et al. (2018) report on the localization, functions, and therapeutic potential of kappa opioid receptors in peripheral sensory neurons.

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