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Health Psychol. 2018 Oct;37(10):929-939. doi: 10.1037/hea0000665.

Development of a lifestyle intervention for the metabolic syndrome: Discovery through proof-of-concept.

Author information

1
Department of Preventive Medicine, Rush University Medical Center.
2
Department of Neurology, Center for Circadian and Sleep Medicine, Feinberg School of Medicine, Northwestern University.
3
Kaiser Permanente Center for Health Research.
4
Department of Psychiatry, Rush University Medical Center.
5
Department of Medicine, Rush University Medical Center.

Abstract

OBJECTIVE:

The aim was to describe the early phases of the progressive development of a lifestyle treatment for sustained remission of the metabolic syndrome (MetS) using the Obesity-Related Behavioral Intervention Trials (ORBIT) model for behavioral treatment development as a guide.

METHODS:

Early discovery and design phases produced a 3-component (diet, physical activity, stress), group-based lifestyle treatment with an intensive 6-month phase followed by monthly, participant-led maintenance meetings. In the proof-of-concept phase, 26 participants with the MetS (age 53 ± 7 years, 77% female, and 65% ethnic minority) were recruited in a quasi-experimental design to determine if treatment could achieve the prespecified benchmark of MetS remission in ≥50% at 2.5 years. Exploratory outcomes focused on MetS components, weight, and patient-centered benefits on energy/vitality and psychosocial status.

RESULTS:

MetS remission was achieved in 53.8% after a median of 2.5 years. At 2.5 years, an increase of +15.4% reported eating ≥3 servings of vegetables/day, +7.7% engaged in ≥150 minutes of moderate-to-vigorous physical activity/week; and +11.5% reported experiencing no depression in the past 2 weeks. Weight loss ≥5% was achieved by 38.5%, and energy/vitality, negative affect, and social support improved. Median group attendance over 2.5 years was 73.8%.

CONCLUSIONS:

It is plausible that this lifestyle program can produce a remission in the MetS, sustained through 2.5 years. After refinements to enhance precision and strength, progression to feasibility pilot testing and a randomized clinical trial will determine its efficacy as a cost-effective lifestyle option for managing the MetS in the current health care system. (PsycINFO Database Record

PMID:
30234352
DOI:
10.1037/hea0000665
[Indexed for MEDLINE]

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