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J Cardiovasc Transl Res. 2018 Oct;11(5):420-428. doi: 10.1007/s12265-018-9822-0. Epub 2018 Sep 19.

Transplantation of Cardiac Mesenchymal Stem Cell-Derived Exosomes Promotes Repair in Ischemic Myocardium.

Author information

1
Department of Cardiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China.
2
Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.
3
Department of Cardiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China. liunf@seu.edu.cn.
4
Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA. yaotang@augusta.edu.

Abstract

Our previous study demonstrated the beneficial effects of exosomes secreted by cardiac mesenchymal stem cells (C-MSC-Exo) in protecting acute ischemic myocardium from reperfusion injury. Here, we investigated the effect of exosomes from C-MSC on angiogenesis in ischemic myocardium. We intramyocardially injected C-MSC-Exo or PBS into the infarct border zone after induction of acute mouse myocardial infarction (MI). We observed that hearts treated with C-MSC-Exo exhibit improved cardiac function compared to control hearts treated with PBS at one month after MI. Capillary density and Ki67-postive cells were significantly higher following treatment with C-MSC-Exo as compared with PBS. Moreover, C-MSC-Exo treatment increased cardiomyocyte proliferation in infarcted hearts. In conclusion, intramyocardial delivery of C-MSC-Exo after myocardial infarction enhances cardiac angiogenesis, promotes cardiomyocyte proliferation, and preserves heart function. C-MSC-Exo constitute a novel form of cell-free therapy for cardiac repair.

KEYWORDS:

Angiogenesis; Cardiac mesenchymal stem cells; Exosomes; Myocardial infarction

PMID:
30232729
PMCID:
PMC6212335
[Available on 2019-10-01]
DOI:
10.1007/s12265-018-9822-0
[Indexed for MEDLINE]

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