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Arch Gynecol Obstet. 2018 Nov;298(5):1017-1027. doi: 10.1007/s00404-018-4884-4. Epub 2018 Sep 19.

Factors affecting the live-birth rate in women with diminished ovarian reserve undergoing IVF-ET.

Author information

1
Key Laboratory of Reproductive Genetics (Ministry of Education), and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, People's Republic of China.
2
Department of Public Health, Institute of Environmental Health, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
3
Key Laboratory of Reproductive Genetics (Ministry of Education), and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, People's Republic of China. zhangdan@zju.edu.cn.

Abstract

PURPOSE:

The occurrence of diminished ovarian reserve (DOR) in women was growing in recent years. Although in vitro fertilization and embryo transfer (IVF-ET) became an effective treatment for DOR, the live-birth (LB) rate remains unsatisfactory. This study aimed to investigate the impact factors of LB rate in women with DOR undergoing assisted reproduction.

METHODS:

This was a single-center retrospective cohort study. A total of 2277 IVF-ET or ICSI cycles from 1957 DOR women were analysed. Impact factors of LB rate were explored via Student's t test, Pearson's Chi-square test, and multivariate logistic regression models.

RESULTS:

There were statistically significant differences in maternal age (P < 0.001), duration of infertility (P < 0.001), female body mass index (P = 0.039), first IVF cycle (P = 0.004), poor ovarian response (P < 0.001), paternal age (P < 0.001), total gonadotropin dose (P = 0.010), endometrial thickness (P = 0.021), number of follicles ≥ 14 mm (P = 0.007), number of oocytes retrieved (P < 0.001), number of frozen embryos (P = 0.014), and the stage (P < 0.001) and number (P < 0.001) of embryos transferred between the non-live-birth (NLB) and LB groups. However, only factors of maternal age, the stage and number of embryos transferred remained different after adjusting for potential confounders.

CONCLUSIONS:

Maternal age, the stage and number of embryos transferred were independent impact factors affecting the live-birth rate in women with DOR seeking for assisted conception.

KEYWORDS:

Cohort study; Diminished ovarian reserve; Impact factors; In vitro fertilization and embryo transfer; Live-birth rate

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