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Biol Res. 2018 Sep 19;51(1):35. doi: 10.1186/s40659-018-0184-5.

Thiamine deficiency contributes to synapse and neural circuit defects.

Author information

1
Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
2
Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. sangshaoming6202@126.com.
3
Institutes of Brain Science & Collaborative Innovation Center for Brain Science, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200032, China. sangshaoming6202@126.com.
4
Institutes of Brain Science & Collaborative Innovation Center for Brain Science, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200032, China.

Abstract

BACKGROUND:

The previous studies have demonstrated the reduction of thiamine diphosphate is specific to Alzheimer's disease (AD) and causal factor of brain glucose hypometabolism, which is considered as a neurodegenerative index of AD and closely correlates with the degree of cognitive impairment. The reduction of thiamine diphosphate may contribute to the dysfunction of synapses and neural circuits, finally leading to cognitive decline.

RESULTS:

To demonstrate this hypothesis, we established abnormalities in the glucose metabolism utilizing thiamine deficiency in vitro and in vivo, and we found dramatically reduced dendrite spine density. We further detected lowered excitatory neurotransmission and impaired hippocampal long-term potentiation, which are induced by TPK RNAi in vitro. Importantly, via treatment with benfotiamine, Aβ induced spines density decrease was considerably ameliorated.

CONCLUSIONS:

These results revealed that thiamine deficiency contributed to synaptic dysfunction which strongly related to AD pathogenesis. Our results provide new insights into pathogenesis of synaptic and neuronal dysfunction in AD.

KEYWORDS:

Alzheimer’s disease; Amyloid-β; Synaptic dysfunction; Thiamine deficiency

PMID:
30231926
PMCID:
PMC6145320
DOI:
10.1186/s40659-018-0184-5
[Indexed for MEDLINE]
Free PMC Article

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