Format

Send to

Choose Destination
Cranio. 2018 Sep 20:1-13. doi: 10.1080/08869634.2018.1516183. [Epub ahead of print]

Liquid platelet-rich fibrin injections as a treatment adjunct for painful temporomandibular joints: preliminary results.

Author information

1
a Private Practitioner and Attending, Division of Oral and Maxillofacial Surgery, Department of Dentistry , Jewish General Hospital , Montreal , Canada.
2
b Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery. FORM (Frankfurt Orofacial Regenerative Medicine) Lab , University Hospital Frankfurt Goethe University , Frankfurt am Main , Germany.
3
c Formerly Department of Anatomy and Cell Biology , McGill University, Montreal, QC, Canada; Currently, MD Candidate, New York Medical College , New York, NY , USA.
4
d Private Practitioner , Pain Therapy Center , Nice , France.
5
e Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, FORM (Frankfurt Orofacial Regenerative Medicine) Lab , University Hospital Frankfurt Goethe University , Frankfurt am Main , Germany.

Abstract

OBJECTIVE:

To evaluate the clinical benefits of liquid platelet-rich fibrin (PRF) in patients with temporomandibular joint (TMJ) pain and dysfunction.

METHODS:

Forty-eight TMJs in 37 patients with painful internal derangement (ID) (Wilkes' I-V) were included. Patients were injected with 1.5-2cc of PRF within the superior joint space at 2-week intervals. Pain and subjective dysfunction were recorded using a visual analog scale. Statistical analyses were done using the ANOVA test.

RESULTS:

Thirty-three of 48 TMJs (69%) showed significant reduction in pain at 8 weeks, and at 3, 6, and 12 months (Responders). Fifteen of 48 TMJs (31%) did not improve (Non-responders). The best Responders to liquid PRF injections were ID stages Wilkes' IV (78.5%) and V (100%), compared to Wilkes' I (0%), II (47%), and III (33%). A non-significant, but notable decrease in dysfunction was found.

CONCLUSION:

Preliminary findings support that liquid PRF exhibits long-term analgesic effects in most patients with painful TMJ ID.

KEYWORDS:

Arthritis; LSCC; TMJ internal derangement; i-PRF; liquid platelet-rich fibrin; low-speed centrifugation concept; pain; tissue engineering

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center