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Int J Environ Res Public Health. 2018 Sep 18;15(9). pii: E2036. doi: 10.3390/ijerph15092036.

Relationship of Time-Activity-Adjusted Particle Number Concentration with Blood Pressure.

Corlin L1,2, Ball S3,4, Woodin M5,6, Patton AP7,8, Lane K9, Durant JL10, Brugge D11,12,13.

Author information

1
Department of Civil and Environmental Engineering, Tufts University School of Engineering, 200 College Ave, Medford, MA 02155, USA. lauracorlin25@gmail.com.
2
Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, 801 Massachusetts Avenue, Suite 470, Boston, MA 02118, USA. lauracorlin25@gmail.com.
3
Department of Civil and Environmental Engineering, Tufts University School of Engineering, 200 College Ave, Medford, MA 02155, USA. shannon.ball94@gmail.com.
4
Department of Public Health and Community Medicine, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA. shannon.ball94@gmail.com.
5
Department of Civil and Environmental Engineering, Tufts University School of Engineering, 200 College Ave, Medford, MA 02155, USA. mark.woodin@tufts.edu.
6
Department of Public Health and Community Medicine, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA. mark.woodin@tufts.edu.
7
Department of Civil and Environmental Engineering, Tufts University School of Engineering, 200 College Ave, Medford, MA 02155, USA. apatton@healtheffects.org.
8
Health Effects Institute, 75 Federal Street, Suite 1400, Boston, MA 02110, USA. apatton@healtheffects.org.
9
Department of Environmental Health, Boston University School of Public Health, 715 Albany St, Boston, MA 02118, USA. klane@bu.edu.
10
Department of Civil and Environmental Engineering, Tufts University School of Engineering, 200 College Ave, Medford, MA 02155, USA. john.durant@tufts.edu.
11
Department of Civil and Environmental Engineering, Tufts University School of Engineering, 200 College Ave, Medford, MA 02155, USA. doug.brugge@gmail.com.
12
Department of Public Health and Community Medicine, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA. doug.brugge@gmail.com.
13
Tufts University Jonathan M. Tisch College of Civic Life, 35 Professors Row, Medford, MA 02155, USA. doug.brugge@gmail.com.

Abstract

Emerging evidence suggests long-term exposure to ultrafine particulate matter (UFP, aerodynamic diameter < 0.1 µm) is associated with adverse cardiovascular outcomes. We investigated whether annual average UFP exposure was associated with measured systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), and hypertension prevalence among 409 adults participating in the cross-sectional Community Assessment of Freeway Exposure and Health (CAFEH) study. We used measurements of particle number concentration (PNC, a proxy for UFP) obtained from mobile monitoring campaigns in three near-highway and three urban background areas in and near Boston, Massachusetts to develop PNC regression models (20-m spatial and hourly temporal resolution). Individual modeled estimates were adjusted for time spent in different micro-environments (time-activity-adjusted PNC, TAA-PNC). Mean TAA-PNC was 22,000 particles/cm³ (sd = 6500). In linear models (logistic for hypertension) adjusted for the minimally sufficient set of covariates indicated by a directed acyclic graph (DAG), we found positive, non-significant associations between natural log-transformed TAA-PNC and SBP (β = 5.23, 95%CI: -0.68, 11.14 mmHg), PP (β = 4.27, 95%CI: -0.79, 9.32 mmHg), and hypertension (OR = 1.81, 95%CI: 0.94, 3.48), but not DBP (β = 0.96, 95%CI: -2.08, 4.00 mmHg). Associations were stronger among non-Hispanic white participants and among diabetics in analyses stratified by race/ethnicity and, separately, by health status.

KEYWORDS:

blood pressure; directed acyclic graph; hypertension; particle number concentration; time-activity adjustment; traffic-related air pollution; ultrafine particulate matter

PMID:
30231494
PMCID:
PMC6165221
DOI:
10.3390/ijerph15092036
[Indexed for MEDLINE]
Free PMC Article

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