Format

Send to

Choose Destination
IUBMB Life. 2018 Dec;70(12):1260-1266. doi: 10.1002/iub.1910. Epub 2018 Sep 19.

The Living Dead: Mitochondria and Metabolic Arrest.

Author information

1
Department of Biology and Institute of Biochemistry, Carleton University, Ottawa, ON, Canada.

Abstract

Mitochondria are not just the powerhouses of the cell; these 'end of function' organelles are crucial components of cellular physiology and influence many central metabolic and signaling pathways that support complex multicellular life. Not surprisingly, these organelles play vital roles in adaptations for extreme survival strategies including hibernation and freeze tolerance, both of which are united by requirements for a strong reduction and reprioritization of metabolic processes. To facilitate metabolic rate depression, adaptations of all aspects of mitochondrial function are required, including; energetics, physiology, abundance, gene regulation, and enzymatic controls. This review discusses these factors with a focus on the stress-specific nature of mitochondrial genes and transcriptional regulators, and processes including apoptosis and chaperone protein responses. We also analyze the regulation of glutamate dehydrogenase and pyruvate dehydrogenase, central mitochondrial enzymes involved in coordinating the shifts in metabolic fuel use associated with extreme survival strategies. Finally, an emphasis is given to the novel mitochondrial research areas of microRNAs, peptides, epigenetics, and gaseous mediators and their potential roles in facilitating hypometabolism.

KEYWORDS:

freeze tolerance; hibernation; hypometabolism

PMID:
30230676
DOI:
10.1002/iub.1910

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center