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Med Sci (Paris). 2018 Aug-Sep;34(8-9):701-708. doi: 10.1051/medsci/20183408017. Epub 2018 Sep 19.

[Even the Warburg effect can be oxidized: metabolic cooperation and tumor development].

[Article in French]

Author information

1
Équipe labellisée par la Ligue nationale contre le cancer, Clinical and experimental model of lymphomagenesis, Univ Lyon, Université Claude Bernard Lyon1, Inserm 1052, CNRS 5286, Centre Léon Bérard, Centre de recherche en cancérologie de Lyon, 165, chemin du Grand Revoyet, 69221 Oullins, France.
2
Institute for Advanced Biosciences, Inserm U1209, CNRS UMR5309, Université Grenoble Alpes, 38000 Grenoble, France.
3
Laboratoire de bioénergétique fondamentale et appliquée, Inserm U1055, 38000 Grenoble, France.

Abstract

During tumor development, malignant cells rewire their metabolism to meet the biosynthetic needs required to increase their biomass and to overcome their microenvironment constraints. The sustained activation of aerobic glycolysis, also called Warburg effect, is one of these adaptative mechanisms. The progresses in this area of research have revealed the flexibility of cancer cells that alternate between glycolytic and oxidative metabolism to cope with their conditions of development while sharing their energetic resources. In this survey, we review these recent breakthroughs and discuss a model that likens tumor to an evolutive metabolic ecosystem. We further emphasize the ensuing therapeutic applications that target metabolic weaknesses of neoplastic cells.

PMID:
30230466
DOI:
10.1051/medsci/20183408017
[Indexed for MEDLINE]

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