Format

Send to

Choose Destination
Inflammopharmacology. 2018 Dec;26(6):1359-1373. doi: 10.1007/s10787-018-0531-8. Epub 2018 Sep 18.

The significant impact of apigenin on different aspects of autoimmune disease.

Author information

1
Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Box 8174673461, Isfahan, Iran.
2
Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Box 8174673461, Isfahan, Iran. neskandari@med.mui.ac.ir.
3
Department of Physiology, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. neskandari@med.mui.ac.ir.

Abstract

Autoimmune diseases are among the highest diseases to diagnose and treat. The current "gold standard" of care for these diseases is immunosuppressive drugs which interfere with overall immune responses; their long-term high-dose treatments would expose the patient to opportunistic, life-threatening and long-term malignant infections. Considering the side effects and toxicity of these drug and also the beneficial effects of herbal compounds among their consumers, the professional investigation on the exact mechanism of the plant's major element has grown much attention in the last years. Apigenin as an extracting compound of plants, such as parsley and celery, which has a variety of biological effects, such as anti-inflammatory, anti-cancer and antioxidant effects. This review is intended to summarize the various effects of Apigenin on several autoimmune diseases which have been worked on so far. The pluralization of the obtained results has revealed Apigenin's effects on pro-inflammatory cytokines such as IL-1β, chemokines such as ICAM-1, immune cells proliferation such as T cells, apoptosis, and various signaling pathways. According to these preclinical findings, we recommend that further robust unbiased studies should be done to use Apigenin as a supplementary or therapeutic element in autoimmune disease.

KEYWORDS:

Apigenin; Autoimmune; Flavonoid; Immunosuppressive drugs

PMID:
30229507
DOI:
10.1007/s10787-018-0531-8
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center