Format

Send to

Choose Destination
Eur J Health Econ. 2018 Sep 18. doi: 10.1007/s10198-018-1007-x. [Epub ahead of print]

Advanced therapy medicinal products and health technology assessment principles and practices for value-based and sustainable healthcare.

Author information

1
Department of Economics, Stockholm School of Economics, Stockholm, Sweden. Bengt.Jonsson@hhs.se.
2
Office of Health Economics, London, UK.
3
University of Sheffield, Sheffield, UK.
4
Leibniz University Hannover, Hannover, Germany.
5
Medi-Qualite Omega, Paris, France.

Abstract

BACKGROUND:

Advanced therapy medicinal products (ATMPs) are beginning to reach European markets, and questions are being asked about their value for patients and how healthcare systems should pay for them.

OBJECTIVES:

To identify and discuss potential challenges of ATMPs in view of current health technology assessment (HTA) methodology-specifically economic evaluation methods-in Europe as it relates to ATMPs, and to suggest potential solutions to these challenges.

METHODS:

An Expert Panel reviewed current HTA principles and practices in relation to the specific characteristics of ATMPs.

RESULTS:

Three key topics were identified and prioritised for discussion-uncertainty, discounting, and health outcomes and value. The panel discussed that evidence challenges linked to increased uncertainty may be mitigated by collection of follow-on data, use of value of information analysis, and/or outcomes-based contracts. For discount rates, an international, multi-disciplinary forum should be established to consider the economic, social and ethical implications of the choice of rate. Finally, consideration of the feasibility of assessing the value of ATMPs beyond health gain may also be key for decision-making.

CONCLUSIONS:

ATMPs face a challenge in demonstrating their value within current HTA frameworks. Consideration of current HTA principles and practices with regards to the specific characteristics of ATMPs and continued dialogue will be key to ensuring appropriate market access.

CLASSIFICATION CODE:

I.

KEYWORDS:

Advanced therapy medicinal products; Cell therapy; Gene therapy; Health technology assessment; Regenerative medicine; Value

PMID:
30229376
DOI:
10.1007/s10198-018-1007-x

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center