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J Exp Med. 2018 Oct 1;215(10):2483-2484. doi: 10.1084/jem.20181503. Epub 2018 Sep 18.

PreB cells are moving on.

Author information

1
Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY.
2
Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY Susan.Schwab@med.nyu.edu.

Abstract

In this issue of JEM, Fistonich et al. (https://doi.org/10.1084/jem.20180778) address how the bone marrow microenvironment supports diverse lineages through multiple developmental stages. Differential motility between pro- and preB cells results in differential IL-7 exposure, and, intriguingly, stromal cells respond to abnormal B cells by reducing Il7.

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