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Neurosci Res. 2019 Jan;138:79-83. doi: 10.1016/j.neures.2018.09.006. Epub 2018 Sep 15.

Timing matters: A strategy for neurons to make diverse connections.

Author information

1
Division of Brain Function, National Institute of Genetics, 1111 Yata, Mishima, 411-8540, Japan; SOKENDAI (Graduate University for Advanced Studies), Japan. Electronic address: tathirat@nig.ac.jp.
2
Division of Brain Function, National Institute of Genetics, 1111 Yata, Mishima, 411-8540, Japan.

Abstract

Neurogenesis proceeds like a continuous wave, in which each type of neurons is produced over a few days to several days. During this protracted time window, early-born and late-born neurons are sequentially produced with a considerable time lag. Even if they are identical in their genetic and molecular specifications, they could develop different characteristics under the influences of the timing of their birth. In this review, we discuss the potential influences of "timing" as a generic parameter affecting neuronal differentiation, particularly on axon guidance and connections. These ideas have rarely been tested experimentally, but may provide a new strategy by which phenotypic diversity is increased in neurons.

KEYWORDS:

Axon guidance; Development; Neurogenesis; Neuronal birthdate; Timing

PMID:
30227163
DOI:
10.1016/j.neures.2018.09.006
[Indexed for MEDLINE]

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