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Mol Imaging Biol. 2018 Sep 17. doi: 10.1007/s11307-018-1275-y. [Epub ahead of print]

Correlation of Tumor Perfusion Between Carbon-13 Imaging with Hyperpolarized Pyruvate and Dynamic Susceptibility Contrast MRI in Pre-Clinical Model of Glioblastoma.

Author information

1
Department of Radiology, Chonnam National University Medical School, Jeabongro 42, Donggu, Gwangju, 61469, South Korea. ipark@jnu.ac.kr.
2
Department of Radiology, Chonnam National University Hospital, Gwangju, South Korea. ipark@jnu.ac.kr.
3
Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.

Abstract

PURPOSE:

The purpose of this study was to compare C-13 imaging parameters with hyperpolarized [1-13C]pyruvate with conventional gadolinium (Gd)-based perfusion weighted imaging using an orthotopic xenograft model of human glioblastoma multiforme (GBM).

PROCEDURES:

C-13 3D magnetic resonance spectroscopic imaging (MRSI) data were obtained from 14 tumor-bearing rats after the injection of hyperpolarized [1-13C]pyruvate at a 3T scanner. Dynamic susceptibility contrast (DSC) perfusion-weighted MR images were obtained following intravenous administration of Gd-DTPA. Normalized lactate, pyruvate, total carbon, and lactate to pyruvate ratio from C-13 MRSI data were compared with normalized peak height and percent recovery of ΔR2* curve from the DSC images in the voxels containing tumor using a Pearson's linear correlation.

RESULTS:

Normalized peak height from DSC imaging showed substantial correlations with normalized lactate (r = 0.6, p = 0.02) and total carbon (r = 0.6, p = 0.02) from hyperpolarized C-13 MRSI data.

CONCLUSIONS:

Since the peak height in the ΔR2* curve from DSC data is related to the extent of blood volume, these hyperpolarized C-13 imaging parameters may be used to assess blood volume in rodent intracranial xenograft models of GBM.

KEYWORDS:

Brain tumor; Dynamic nuclear polarization; Dynamic susceptibility contrast imaging; Glioblastoma; Hyperpolarized carbon-13; Magnetic resonance spectroscopic imaging; Perfusion; Pyruvate

PMID:
30225760
DOI:
10.1007/s11307-018-1275-y

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