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Sci Rep. 2018 Sep 17;8(1):13938. doi: 10.1038/s41598-018-32044-7.

Assembly of Plasmonic and Magnetic Nanoparticles with Fluorescent Silica Shell Layer for Tri-functional SERS-Magnetic-Fluorescence Probes and Its Bioapplications.

Author information

1
Department of Bioscience and Biotechnology, Konkuk University, Seoul, 05029, Republic of Korea.
2
School of Chemical and Biological Engineering, Seoul National University, Seoul, 08826, Republic of Korea.
3
Department of Chemistry Education, Seoul National University, Seoul, 08826, Republic of Korea.
4
School of Chemical and Biological Engineering, Seoul National University, Seoul, 08826, Republic of Korea. yslee@snu.ac.kr.
5
Department of Bioscience and Biotechnology, Konkuk University, Seoul, 05029, Republic of Korea. kimde@konkuk.ac.kr.
6
Department of Bioscience and Biotechnology, Konkuk University, Seoul, 05029, Republic of Korea. bjun@konkuk.ac.kr.

Abstract

In this study, we report on the fabrication of multilayered tri-functional magnetic-SERS-fluorescence nanoprobes (MF-SERS particles) containing clustered superparamagnetic Fe3O4 nanoparticles (NPs), silver NPs, and a fluorescent silica layer. The MF-SERS particles exhibited strong SERS signals from the silver NPs as well as both superparamagnetism and fluorescence. MF-SERS particles were uptaken by cells, allowing successful separation using an external magnetic field. SERS and fluorescence signals could be detected from the NP-containing cells, and CD44 antibody-conjugated MF-SERS particles selectively targeted MDA-MB-231 cells. Based on these properties, MF-SERS particles proved to be a useful nanoprobe for multiplex detection and separation of cancer cells.

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