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Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e01371-18. doi: 10.1128/AAC.01371-18. Print 2018 Dec.

Beyond Penicillin: Rapid Desensitization for Specific Flucloxacillin Hypersensitivity.

Author information

1
Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.
2
Department of Pharmacy, Austin Health, Heidelberg, Victoria, Australia.
3
National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
4
Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia jason.trubiano@austin.org.au.
5
Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.

Abstract

Beta-lactam therapy for severe staphylococcal infections is associated with superior outcomes, compared to non-beta-lactam therapy. For patients with immediate hypersensitivity to beta-lactams, desensitization has been widely employed to allow beta-lactam therapy, but published protocols for antistaphylococcal beta-lactams such as flucloxacillin are lacking. Here, we report a case and describe the desensitization protocol successfully used for a patient with isolated flucloxacillin immediate hypersensitivity, for whom a penicillin desensitization protocol would likely have resulted in an adverse drug reaction.

KEYWORDS:

anaphylaxis; antibiotic allergy; desensitization; flucloxacillin; hypersensitivity; penicillin allergy

PMID:
30224537
PMCID:
PMC6256748
DOI:
10.1128/AAC.01371-18
[Indexed for MEDLINE]
Free PMC Article

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