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Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e01587-18. doi: 10.1128/AAC.01587-18. Print 2018 Dec.

Antimicrobial Susceptibility of Pseudomonas aeruginosa to Ceftazidime-Avibactam, Ceftolozane-Tazobactam, Piperacillin-Tazobactam, and Meropenem Stratified by U.S. Census Divisions: Results from the 2017 INFORM Program.

Author information

1
JMI Laboratories, North Liberty, Iowa, USA helio-sader@jmilabs.com.
2
JMI Laboratories, North Liberty, Iowa, USA.

Abstract

Pseudomonas aeruginosa isolates (n = 1,909) were collected from 70 U.S. medical centers, and their susceptibilities were tested using the broth microdilution method. Ceftazidime-avibactam (MIC50/MIC90, 2/8 mg/liter) and ceftolozane-tazobactam (MIC50/MIC90, 0.5/2 mg/liter) were the most active (i.e., had the highest susceptibility rates) compounds after colistin, with national susceptibility rates of 96.9% and 97.5%, respectively. Overall, piperacillin-tazobactam (MIC50/MIC90, 4/128 mg/liter) and meropenem (MIC50/MIC90, 0.5/16 mg/liter) were active against 77.5% and 76.0% of the isolates, respectively. Susceptibility variations across census divisions were documented for many antimicrobials.

KEYWORDS:

Pseudomonas aeruginosa ; antimicrobial resistance; inhibitor combinations; β-lactamases

PMID:
30224535
PMCID:
PMC6256773
[Available on 2019-05-26]
DOI:
10.1128/AAC.01587-18

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