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Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e01239-18. doi: 10.1128/AAC.01239-18. Print 2018 Dec.

Intrahepatic Administration of Liposomal Amphotericin B (Ambisome) for the Management of a Liver Abscess from Candida albicans in a Preterm Infant.

Author information

1
Department of Medical and Surgical Neonatology, Bambino Gesù Children's Hospital, Rome, Italy cinzia.auriti@opbg.net.
2
Department of Medical and Surgical Neonatology, Bambino Gesù Children's Hospital, Rome, Italy.

Abstract

Hepatic fungal abscesses are rare in the neonatal period and often constitute a severe complication of the catheterization of the umbilical vessels. Such life-threatening lesions are observed more frequently in preterm than in other newborn infants and the optimal treatment remains uncertain. We present the case of a preterm neonate, who developed an intrahepatic lesion due to parenteral extravasation, successively contaminated by Candida albicans Despite the maximal pharmacological therapies, the treatment that led to the definitive resolution of the abscess was the placement of surgical drainage followed by the direct intralesional administration of liposomal amphotericin B (Ambisome), never described in neonates in the literature, which turned out to be a safe and effective approach.

KEYWORDS:

Candida albicans ; liposomal amphotericin B; liver abscess

PMID:
30224526
PMCID:
PMC6256806
[Available on 2019-05-26]
DOI:
10.1128/AAC.01239-18

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