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Int J Mol Sci. 2018 Sep 16;19(9). pii: E2785. doi: 10.3390/ijms19092785.

Molecular Mechanism and Health Role of Functional Ingredients in Blueberry for Chronic Disease in Human Beings.

Ma L1,2, Sun Z3,4, Zeng Y5, Luo M6, Yang J7.

Author information

1
Economics and Management College, Southwest Forestry University, Kunming 650224, China. ma403294928@163.com.
2
Key Laboratory for Forest Resources Conservation and Utilisation in the Southwest Mountains of China, Southwest Forestry University, Ministry of Education, Kunming 650224, China. ma403294928@163.com.
3
Economics and Management College, Southwest Forestry University, Kunming 650224, China. sunzhenghai1978@163.com.
4
Key Laboratory for Forest Resources Conservation and Utilisation in the Southwest Mountains of China, Southwest Forestry University, Ministry of Education, Kunming 650224, China. sunzhenghai1978@163.com.
5
Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences, Kunming 650205, China. zengyw1967@126.com.
6
Key Laboratory for Forest Resources Conservation and Utilisation in the Southwest Mountains of China, Southwest Forestry University, Ministry of Education, Kunming 650224, China. lmc1961@sohu.com.
7
Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences, Kunming 650205, China. yangjiazhen415@163.com.

Abstract

Functional ingredients in blueberry have the best health benefits. To obtain a better understanding of the health role of blueberry in chronic disease, we conducted systematic preventive strategies for functional ingredients in blueberry, based on comprehensive databases, especially PubMed, ISI Web of Science, and CNKI for the period 2008⁻2018. Blueberry is rich in flavonoids (mainly anthocyanidins), polyphenols (procyanidin), phenolic acids, pyruvic acid, chlorogenic acid, and others, which have anticancer, anti-obesity, prevent degenerative diseases, anti-inflammation, protective properties for vision and liver, prevent heart diseases, antidiabetes, improve brain function, protective lung properties, strong bones, enhance immunity, prevent cardiovascular diseases, and improve cognitive decline. The anthocyanins and polyphenols in blueberry are major functional ingredients for preventive chronic disease. These results support findings that blueberry may be one of the best functional fruits, and further reveals the mechanisms of anthocyanins and polyphenols in the health role of blueberry for chronic disease. This paper may be used as scientific evidence for developing functional foods, nutraceuticals, and novel drugs of blueberry for preventive chronic diseases.

KEYWORDS:

blueberry; chronic disease; functional food; functional ingredients

PMID:
30223619
PMCID:
PMC6164568
DOI:
10.3390/ijms19092785
[Indexed for MEDLINE]
Free PMC Article

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