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Prostaglandins Other Lipid Mediat. 2018 Nov;139:1-9. doi: 10.1016/j.prostaglandins.2018.09.002. Epub 2018 Sep 14.

Omega-3 PUFA attenuate mice myocardial infarction injury by emerging a protective eicosanoid pattern.

Author information

1
Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China.
2
Tianjin Key Laboratory of Metabolic Diseases and Department of Physiology, Tianjin Medical University, Tianjin, China.
3
Department of Entomology and Comprehensive Cancer Center, University of California Davis, Davis, California, USA.
4
Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China; Tianjin Key Laboratory of Metabolic Diseases and Department of Physiology, Tianjin Medical University, Tianjin, China.
5
Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China; Tianjin Key Laboratory of Metabolic Diseases and Department of Physiology, Tianjin Medical University, Tianjin, China. Electronic address: xuzhang@tmu.edu.cn.

Abstract

Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation is a recommended preventive approach against cardiovascular diseases, but its mechanism of protection against myocardial infarction (MI) injury is not fully understood. Eicosanoid metabolomics demonstrated an abnormal eicosanoid profile was in the plasma of mice receiving MI surgery. 19,20-EDP, 17,18-EEQ, 14,15-EET and 9,10-EpOME were decreased, and PGE2 was increased by the surgery. N-3 PUFA-rich diets feeding or transgene of Fat-1 shifted the eicosanoid profile to an n-3 PUFA dominant style and attenuated the myocardial infarction injury. Multiple logistic regression analysis suggested the degree of MI injury was related with an eicosanoid pattern, composed by eicosanoids derived from both n-3 and n-6 PUFA in the three enzymatic pathways. These results suggested the benefits of n-3 PUFA on MI was achieved synergistically.

KEYWORDS:

Eicosanoid; Metabolomics; Myocardial infarction; Omega-3 PUFA

[Indexed for MEDLINE]

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