Format

Send to

Choose Destination
N Engl J Med. 2018 Oct 18;379(16):1509-1518. doi: 10.1056/NEJMoa1805819. Epub 2018 Sep 16.

Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly.

Collaborators (2137)

Chan A, Demons J, Espinoza S, Goetz M, Liew D, Meyskens F, Zalcberg J, Ives D, Berk M, Bernstein W, Brauer D, Burns C, Chong T, Cloud G, Eaton C, Fitzgerald P, Haydon A, Jelinek M, Macrae F, Mahady S, Malik M, McLean C, Rodriguez L, Satterfield S, Tie J, van Londen G, Ward S, Wood E, Mohr J, Anderson G, Connolly S, Friedman L, Manson J, Sano M, Morrison S, Ohman EM, Hadley E, Hannah J, Romashkan S, Ford L, Richmond E, Umar A, Lockett T, Lewis B, Obisesan T, Gilbertson D, Collyer T, Rigby J, Pruksawongsin K, Hay N, Jachno K, Smith C, Ekram ARMS, Gardam M, Luong H, Montgomery T, Plate M, Rojas L, Tominaga A, Wadeson K, Hopkins S, Nichols T, Johnson A, Prozinski M, Robinson-O’Brien R, Tessum N, Aloia J, Anton S, Burns J, Burton G, Ferris D, Honasoge M, Hsia D, Katzman S, Kottam A, Nesbitt S, Ochoa A, Pemu P, Peterson K, Powell J, Pressman G, Robinson W III, Satterfield S, Thorburn C, Volpi E, Wiggins J, Wilson P, Womack C, Abdullah M, Abdul-Ridha S, Aboud E, Abraham A, Abraham J, Abraham K, Abrahams M, Adad S, Adams C, Africa N, Afroze S, Agarwal D, Agbarakwe C, Ah Sang W, Ahern T, Ahmad Y, Ahmad Z, Ahmed L, Ajam A, Akhter R, Akram Z, Alagarswami K, Alam M, Alavi E, Aldridge L, Alethan A, Alexander K, Alexander L, Alexopoulos M, Ali B, Ali M, Allan J, Allen C, Allen G, Allen S, Allin P, Al-Musawy R, Alpren C, Al-Tawil I, Alwyn T, Amor P, Anam T, Anderson G, Anderson L, Anderson N, Anderson P, Anderson R, Anderson-Dalheim H, Andrada E, Andre S, Andrews L, Andric A, Andric M, Ang J, Ansari A, Arakji AM, Arambeploa Y, Ark R, Arnaudon FP, Arndt PM, Aroney T, Arthurson J, Arunachalam T, Asim N, Aslam I, Assad S, Astley N, Athari M, Atkins C, Atkins M, Aufgang M, Aung K, Aurora G, Auteri S, Avergun A, Awwad A, Azad C, Azra S, Babovic A, Baig M, Baker J, Baker S, Baker T, Bakhilova N, Baldam A, Baldassa A, Baldi C, Balkwill C, Balogun O, Ban A, Banerjee P, Banning M, Bansal S, Barkas R, Barker A, Barker D, Barnes A, Barnes N, Barnetson W, Barratt I, Barrett DA, Barrett M, Barrett M, Barrett P, Barrett T, Barson P, Barstad C, Barton W, Bartram M, Bartusek P, Basser S, Bassett S, Batchelor L, Batt D, Batty A, Baum S, Baxter M, Beaton G, Beaumont J, Beavis D, Beckett V, Beech M, Beilby J, Bekal S, Bell A, Bendtsen L, Benedict D, Benjamin T, Bennett P, Bennie G, Bennie S, Bennison S, Benson A, Benson R, Benson S, Bergin J, Bergin S, Berryman G, Berryman J, Bertram H, Bertuch G, Bettenay G, Bettiol L, Bills R, Birch J, Bird R, Bird R, Birks R, Blake R, Blakney A, Blashki M, Bleach G, Bloch B, Bodenstein M, Boga V, Bollen C, Boltin P, Boon B, Booth G, Borg A, Bornstein D, Bottcher C, Bourke J, Bourke M, Boutcher S, Bowden J, Bowen J, Bowring B, Boyce C, Boyd J, Brack R, Bradshaw A, Brady P, Braithwaite J, Braude G, Brayshaw N, Breen M, Bresnahan R, Briddon P, Bridge A, Briggs SJ, Brimage RF, Britten-Jones W, Brkic M, Broadby M, Bromberger D, Brommeyer A, Broom I, Brophy T, Brough J, Brougham JP, Broun C, Brown ID, Brown J, Brown MB, Brown MP, Brown R, Brownbill C, Brownbill L, Browne M, Brownstein M, Bruce A, Brunacci F, Brunner C, Bruorton M, Buccheri V, Buchanan D, Buckley J, Bulle B, Bundy K, Burke M, Busch G, Bush CP, Butrev A, Bvirakare J, Bvumbura BF, Bye J, Byrne C, Byrne P, Cain M, Calcutt I, Calder K, Caldwell M, Callan C, Cameron A, Cameron D, Cameron D, Cameron T, Campbell D, Campbell D, Campbell G, Campbell G, Campbell PH, Campbell R, Carroll N, Carroll V, Carson J, Carson R, Carter L, Carter P, Carter R, Carter S, Cartwright P, Cassidy P, Catchpole M, Cato G, Celada R, Chai F, Chalabi A, Chalissery P, Chalmers ML, Chamberlain H, Chamoun R, Chan B, Chan C, Chan CK, Chan FW, Chan K, Chandran S, Chandrananth M, Chandrananth S, Chang C, Chang V, Chang W, Changakoti A, Chantler R, Chao D, Chao S, Charlton P, Chattersee A, Chau G, Chaung Y, Chawtur V, Cheah HH, Cheah S, Cheasley A, Chee H, Chen D, Cheng W, Chesney D, Chew D, Chhabra P, Chia I, Chia P, Chiang A, Chiang S, Chiew I, Chiew L, Chikarsal A, Chin J, Chin M, Chipman JS, Chipperfield C, Chisholm H, Chisholm L, Chiu A, Chiu C, Chiu D, Chiu T, Chizik L, Choksey H, Choo E, Chow A, Chow A, Choy C, Chu S, Chua A, Chuah T, Chung J, Cimpoescu T, Clapton J, Clark B, Clark B, Clark M, Clark R, Clarke A, Clarke D, Clarke S, Cleary G, Clerigo L, Clohesy S, Close S, Cochrane F, Cohen IS, Cohen J, Colahan R, Collins J, Colman W, Colvin R, Conde S, Connell P, Connellan M, Connor W, Connors G, Conos M, Conron D, Conroy J, Conway C, Cooper M, Cooper S, Cope A, Corrigan S, Corrigan S, Coughlan P, Coulter E, Counsel L, Court D, Courtis G, Cousens A, Craig L, Crameri M, Cranswick M, Crawford J, Crawford M, Crawford P, Crawford R, Crick S, Crimmins B, Cristofaro R, Croatto J, Crompton A, Cronin E, Crookes J, Cross B, Cross D, Cross M, Crow P, Crowe JE, Crowe P, Crowley H, Cruickshank J, Cummins R, Cunneen A, Cunningham A, Cunningham N, Cunningham P, Curnow D, Curran J, Curran M, Currie A, Curtis R, Cusack J, Dabash K, Dabestani V, Dadabhay Z, Daglas D, Dagley P, Danesh S, Dang D, Daniels R, Darby JP, Darko N, Darling J, Darlington B, Das J, Das P, Date M, Datta C, Datta S, Davenport C, Davey G, Davey M, Davey P, Davidson CL, Davidson D, Davies M, Davies-Hakeem A, Davis G, Davis K, Davis P, Davis P, Davis S, Dawe N, Dawes R, Dawkins P, Dawson G, Dawson P, Dawson R, Day P, Daya M, Dayasagar D, D’Costa L, De Clifford M, De Gleria S, De Poi C, De Silva M, De Silva P, De Steiger R, De Villiers D, De Wit E, Debnath R, Deery R, De Lanerolle D, Del Rio F, Delaney S, Delitzsch SS, Demaio F, Demian M, Demirtzoglou J, Denton T, Derrick L, Deshmukh K, Dessauer J, Devavittiya C, Devereux D, Dewan D, Dewhurst H, Dhar A, Dhillon D, Di Carlo M, Di Dio A, Di Marco A, Dickman J, Dillon L, Dinh QT, Dissanayake D, Dissanayake M, Dissanayake T, Divakaran K, Dixit U, Dixon H, Dixon N, Djakic E, Dobson C, Dodd L, Dodds P, Dodic A, Dodic M, Doley A, Dolguina S, Dolling C, Donaghy F, Donald H, Donelan E, Donohue M, Dooland J, Dooley H, Doslo S, Douglas A, Dover P, Downe G, Drake P, Dry D, Duane P, Dubash A, Dubetz D, Duff P, Duke R, Dumitrescu C, Dunbar A, Dunbar S, Dunn S, Duong NH, Dutta N, Dutton M, Duval A, Dyson-Berry J, Eade P, Eaton D, Ebert K, Edib K, Edillo E, Edmonds J, Edwards F, Edwards PA, Edwards S, Eftekharuddin M, Egan A, Egan P, Ehrenreich S, Ehsan E, Elberg L, Elisha B, Elisha R, Elkhoury H, Ellerton K, Elliot-Smith A, Elmore R, Elshenawy I, Elsherif S, Elsouki M, Elton P, Emmerson M, Emmett SI, English J, Enten P, Entwistle J, Epa W, Erhardt A, Etta J, Evans M, Everitt T, Ewing J, Fahkok B, Faigen M, Fair A, Fairbrother C, Fanning J, Fantasia M, Farag E, Fardell K, Farrant J, Farrell P, Farrow J, Fassett M, Faull PA, Ferguson P, Fernando S, Fernando S, Ferruccio A, Fidge JH, Field P, Figurireo L, Fisher H, Fisher J, Fitzgerald E, Fitzgerald M, Fitzgerald R, Fitzpatrick H, Fitzpatrick J, Fitzpatrick P, Fitzpatrick T, Flaherty P, Flanagan D, Flanagan T, Flew S, Fonseka PP, Foo J, Foo S, Foo Y, Foong E, Ford D, Foster D, Fourlanos V, Fowler I, Fox D, Fox F, Fox M, Fox P, Fox-Smith D, Francis J, Francis R, Frank O, Franks A, Fredericks A, Freeman E, French L, Frew B, Friebel D, Friebel T, Frost S, Fryer D, Fuller J, Fung W, Fung WP, Furphy S, Gabutina C, Gaggin S, Galbraith S, Gale M, Gall J, Gallichio V, Gangell AW, Garde MA, Gardner SS, Gardner T, Garland J, Garra G, Garrow S, Garvey J, Gauden M, Gault A, Gaur D, Gavralas A, George N, George S, Georgy M, Gerendasi R, Geschke H, Giannakakis J, Gidley G, Gilani M, Giles P, Gill K, Gill P, Gill R, Gillis C, Gilmore A, Gilovitz M, Gingold R, Glaspole D, Glowinski L, Glue AL, Godakumbura P, Godavarthy R, Goel A, Goeltom C, Goldberg E, Goldberg J, Golets M, Gong V, Goode J, Goodman C, Goodwin RJ, Gopathy S, Gordon M, Gough S, Govender M, Gow K, Gowrie B, Goy P, Grabowski C, Graddon J, Granek A, Gray JM, Gray M, Gray T, Grbac E, Greacen J, Greculescu E, Green J, Greenwood E, Griffin E, Griffith V, Griffiths A, Griffiths G, Griffiths J, Griffiths K, Grigorian AR, Grinzi P, Grogan H, Grokop G, Grossman L, Grove A, Gruzauskas A, Gu M, Guest S, Guindi N, Guo H, Gurney R, Guy J, Guymer J, Gwynn R, Gyorki J, Habibi S, Hachem C, Hackett A, Hackett J, Haddad J, Haddad M, Hadley E, Hagger R, Haider Z, Hain R, Hajicosta T, Hales P, Hall J, Hall P, Hall R, Hall R, Hall S, Halliburton K, Halliday A, Halliday B, Halliday J, Hamblen K, Hamel J, Hamer I, Hamilton J, Hamilton RF, Hammond T, Hanbury R, Hancock A, Hand R, Hanna A, Hanna M, Hanna S, Hanson G, Hanson PD, Haque E, Haran C, Haran T, Hare WJ, Harewood A, Haripersad S, Harman A, Harmer D, Harms P, Harnden C, Harrington M, Harris A, Harris M, Harrison M, Harrison S, Hart E, Hartley D, Hartley P, Hartnett M, Harvey C, Haslam K, Hassani I, Hassett RB, Hastings W, Hattingh A, Hawke I, Hawkins C, Hayes V, Heale J, Healy G, Hebblewhite A, Hechtman A, Hedgland A, Heffernan C, Heikkinen MN, Heinrich C, Henderson J, Henry F, Herath S, Herbert A, Herbst D, Hermiz S, Herrman J, Hesse M, Hetherington J, Hetzel R, Hewett R, Hides R, Higgins CD, Hildred S, Hill A, Hilton C, Hince R, Hines C, Hinton C, Hipolito A, Ho CK, Ho L, Hoar J, Hocking L, Hodge A, Hodgkins A, Hodgson J, Hogbin J, Hok S, Holder B, Holland D, Holland M, Hollins B, Homewood M, Hong Zhou A, Honig J, Honigman S, Hookham D, Hooper W, Hope L, Horman J, Horng T, Hornstein I, Horriat M, Horvat J, Hossain M, Hough P, Howe J, Howson W, Hubczenko I, Hubel M, Hughes J, Hughes P, Hunter D, Huq S, Hussain A, Hutchins I, Hutchinson A, Hyam P, Hyare K, Iakovidis B, Ibragimov M, Idris M, Ierace C, Ikladios A, Imgraben P, Ingham C, Ip A, Ip Y, Iqbal A, Iqbal M, Irvine G, Irwin V, Iser D, Islam N, Islam S, Isles JK, Ismail A, Ivanoff G, Iwe N, Jackett RB, Jackson M, Jackson N, Jackson P, Jackson T, Jacoup M, Jaensch E, Jain P, Jain S, Jaiswal N, Jaksic A, Jakubowicz I, Jamel B, James J, Jameson D, Jansz C, Jarman E, Jassi I, Jayasinghe S, Jayatilake J, Jayaweera V, Jeanes R, Jeanneret CI, Jedynak S, Jeffries L, Jegadeesh K, Jenkins P, Jennings C, Jenny C, Jiang YY, Jigau C, Jinadasa C, Joel S, John R, Johns P, Johnson C, Johnson J, Johnson M, Johnson N, Johnson W, Johnston B, Johnston K, Johnston M, Johnston R, Johnston T, Jones G, Jones I, Jones L, Jones M, Jones S, Jones T, Jones T, Joshi M, Joshi N, Joshi N, Joske F, Joubert C, Jovanovic B, Joyce R, Judd AM, Judd J, Kaaden JP, Kabat L, Kabourakis F, Kaippilly A, Kajani H, Kamale A, Kaminsky L, Kanapathipillai U, Kanashuk L, Kao R, Kapadia P, Kapadia V, Karmouche R, Kaur KJ, Kavanagh T, Kay A, Kay B, Kaye S, Keane K, Keating B, Keecha E, Keecha J, Keenan P, Keillar P, Kemp G, Kemp P, Kennedy M, Kennedy U, Kennett S, Kesarapu S, Khan F, Khan I, Khan M, Khong CK, Khoo F, Khoo J, Khoo S, Khoshghalb A, Kiefer J, Kiley M, Kilov G, Kimpton N, King SC, Kingston R, Kinsella P, Kipouridis A, Kirwan A, Kisselev S, Kitchen J, Kloot S, Knaggs J, Knight E, Knobel J, Knowles D, Knowles P, Kogosowski S, Kok J, Kok J, Kollios D, Konopnicki H, Koravos A, Korol P, Kosky AR, Kote Somashekarappa M, Kottegoda-Vithana E, Kotur S, Kozminsky M, Kraner G, Kraus DH, Krell I, Kruytbosch C, Kuay V, Kucminska A, Kulatunga P, Kulinski M, Kumar J, Kumar R, Kumar S, Kumarage D, Kumaraswamy S, Kunze M, Kurien S, Kuruvilla P, Kwong R, Kyaw Z, Kyriacopoulos J, Lackner PJ, Lahanis C, Lajoie D, Lajoie K, Lakshmanan A, Lal A, Lalor E, Lam D, Lambooij C, Lancaster M, Landa L, Landers J, Lane R, Langston K, Lapin S, Lath P, Lau-Gooey T, Lawlor-Smith L, Le Couteur S, Le P, Le Riche M, Le V, Le W, Leber D, Ledner A, Lee B, Lee C, Lee D, Lee FB, Lee J, Lee J, Lee JY, Lee J, Lees K, Lees R, Lees W, Leffler P, Lenton J, Leong R, Leow L, Leow P, Leow Y, Leslie N, Lester SE, Lewi L, Lewis P, Lewis R, Li A, Li J, Liang J, Liang X, Libhaber H, Lichtblau B, Lickiss T, Liedvogel M, Liew K, Light L, Lightfoot W, Lim C, Lim D, Lim H, Lim HS, Lim J, Lim SG, Limaye S, Limbu Y, Lindenmayer J, Lindstedt P, Lines A, Ling J, Ling R, Linton J, Linton S, Linton T, Liow C, Liow YC, Lip L, Lipson D, Liu S, Liu Y, Liubinas R, Liveriadis T, Lizner S, Lloyd M, Lo B, Lo C, Lock P, Lockhart M, Logan M, Loke KP, Long M, Long M, Longworth W, Loo KH, Lopez-Hernandez S, Lord RJ, Louw J, Louw TT, Low B, Low F, Lowe M, Lowther D, Loxley P, Lu P, Lu S, Lucarelli A, Lui G, Lui K, Lui R, Luke C, Lukic N, Lupton J, Luscombe T, Luttrell CL, Lyall A, Lynch J, Lynn K, Lyon D, Lyon E, Lyons S, Macaulay G, Macaulay K, MacIndoe A, MacIsaac P, Maciver R, Mackay B, Mackay J, Mackinnon D, Mackle R, Macphail J, Madawala N, Madden J, Madeley C, Madhanpall N, Magarey J, Magill M, Mah S, Mahadeva SP, Mahendran S, Maher J, Maher M, Mahmood A, Mahmood A, Maier K, Majchrzak W, Majeed J, Makar A, Makohon R, Malcher P, Malcolm HE, Malcolm M, Mallett S, Mallik A, Manderson J, Mane S, Mangan G, Manifold M, Manoliadis M, Manovel B, Mansour A, Manton D, Marano F, Marchant D, Mariajoseph G, Marinos A, Marinucci D, Marrows M, Marsh D, Martin C, Martin G, Martin R, Marton F, Martynova L, Mason N, Masood U, Massaud M, Massy-Westropp P, Masters B, Mather J, Mathews RA, Mathieson G, Mauro M, Mauviel PA, Maxfield N, Mayhead C, Mazengiya S, Mazhar A, Mbachilin G, McAllan A, McCallum H, McCann N, McCarthy A, McCleary A, McClelland R, McConville DS, McCorkell J, McCormack G, McCormick H, McCowan M, McCutcheon J, McDonald AG, McDonald AS, McDonald IR, McDonald J, McDonald N, McDonald S, McEniery A, McEntee K, McGee R, McGinity P, McGowan N, McGowan R, McGrath L, McGuire P, McGuire P, McHardy C, McHenry K, McIllree R, McKay M, McKellar C, McKelvie M, McKenzie SI, McKeown J, McKeown M, McKernan S, McKinnon A, McLaren G, McLeod I, McMahon A, McMaster I, McNab NR, McNaughton EL, McNiff M, McPherson C, Meaney J, Medlicott M, Medres R, Megally R, Mehta K, Mellios O, Melvani R, Mencel J, Mendick S, Mendis L, Menzies J, Mercado M, Mesiha S, Meyer PL, Meyer R, Miceli A, Michaelson T, Michail A, Michelmore K, Miezis V, Milan S, Milky S, Miller K, Milner J, Milone R, Milton C, Milward N, Mirhom R, Mirranay S, Mishricky H, Misso R, Mitchell A, Mitchell D, Mitchell L, Mobilia G, Moffitt M, Mohr V, Moller G, Moller G, Molloy P, Molloy T, Molyneux P, Monaghan C, Monash D, Moncrieff S, Monzon M, Mooney T, Moore E, Moran J, Morgan G, Morgan M, Morgan N, Morris N, Morris S, Morrison H, Morrow S, Morton R, Moschou C, Moulding S, Moule V, Mouzakis V, Mudunna D, Mudzi S, Mulkearns P, Mullen D, Mulvey G, Mungi D, Munro L, Muraledaran S, Murphy B, Murphy G, Murray A, Murray B, Murray E, Murray H, Murray S, Murtagh C, Nadarajah M, Naiker S, Naing W, Nandha R, Nankervis J, Naoum A, Nash C, Nashed M, Nasreen N, Nath-Chand U, Neagle M, Nelson C, Nelson MR, Nesbitt P, Neuberger M, Newman S, Newton S, Ng D, Ng H, Ng S, Nguyen D, Nguyen HQ, Nguyen HT, Nguyen T, Nguyen-Ngoc M, Nice P, Nicholls P, Nicholson D, Nicola N, Nicolettou N, Nicolson I, Nield S, Nikolic V, Nikolovska-Buzevski N, Nilsson A, Nimmo A, Nisselle P, Nitchingham S, Niven A, Nnopu E, Noonan L, Norton C, Norton G, Notini G, Nwaegerue ED, Nylander P, O’Brien C, O’Connor A, O’Connor DA, O’Donovan B, O’Driscoll E, Oechsle G, Offor J, Ogilvie B, O’Halloran J, O’Hanlon P, Okolie K, Olaniyi I, O’Leary B, O’Leary K, Olesen J, Oliver P, Olomola O, Olszewski C, Olukolu G, Omarjee A, Omidiora AA, Omifolaji S, O’Neill A, O’Neill CO, Ong BP, Ong M, Ooruthiran M, Oppermann BL, Orbach E, Orgonas R, Orsillo M, Ostberg M, O’Sullivan C, O’Sullivan J, O’Sullivan PJ, O’Toole C, O’Toole M, Otuonye D, Owen T, Padilla C, Page A, Pahuja P, Palmer A, Pan J, Panozzo D, Pantillano E, Papagelis A, Papas E, Pape A, Paransothy P, Parghi N, Parker A, Parker J, Parker S, Parkes H, Parletta E, Parry B, Pasha M, Patel G, Patel M, Pathirana A, Patterson R, Pattichis I, Pattison J, Pava C, Peachey D, Pearce E, Pearce R, Pearse B, Pearson R, Pech M, Peduru-Arachchige A, Pellegrini P, Pellizzari G, Pereira V, Perera B, Perera L, Perlesz A, Perraton R, Perry H, Perry S, Perry W, Pervaiz Z, Peters L, Pham H, Phan C, Phan T, Phare A, Philip J, Philips J, Phillips A, Philpot J, Phiri R, Pickavance M, Piekarski D, Pienkos J, Piez W, Pilgrim C, Pillai BK, Pinder R, Pinkstone J, Pinson J, Pither A, Plenderleith J, Pliatsios B, Plunkett M, Pokharel C, Poland D, Polgar V, Polmear D, Poologanathan G, Pope I, Popp L, Portelli A, Potter T, Powell K, Powell K, Powell V, Power R, Powles A, Poynton N, Pranavan S, Prasad R, Praszkier S, Preiss J, Pretorius P, Price C, Price I, Price K, Price M, Priest C, Pring M, Profitt C, Protassow A, Psaradellis IJA, Psycharis J, Pucilowski D, Pun K, Qamar F, Quach S, Radcliff E, Radcliffe B, Radcliffe J, Radford J, Ragg P, Rahel E, Rahim T, Rahman F, Rahmanamlashi N, Rajasooriar S, Rajendra I, Rajini E, Raman A, Ramsay A, Ramsey J, Rana U, Rankin M, Rao UV, Rapley M, Rasaratnam S, Rashid A, Ratnaike L, Rattan J, Ratten K, Rattraywood C, Rayner E, Rea J, Rea PC, Reddy S, Reddy S, Reed R, Reeves C, Reichl T, Reid J, Reid K, Remyn P, Renfrey S, Renouf E, Renshaw P, Retchford A, Reynolds F, Reza R, Rezk L, Rhee J, Rhodes F, Rice A, Richards J, Richards R, Richardson A, Richardson GT, Richardson R, Richardson T, Ridgers D, Ridgers MJ, Rieger W, Rienits H, Rigoni M, Riley J, Rillstone D, Rimmer DE, Ringelblum D, Riseley J, Roberts A, Roberts I, Roberts J, Roberts M, Roberts S, Robinson J, Robinson R, Robson A, Roche V, Rodda C, Rodway P, Roebuck R, Rogers D, Rogers S, Roman F, Romas D, Ronan C, Rope S, Rose A, Rose DF, Rose G, Rose K, Rosen N, Rosenblatt J, Ross K, Ross M, Ross T, Roth J, Rothfield J, Roubos N, Roufael AD, Rounsevell J, Rouse W, Roushdy B, Rowe R, Rowland G, Roy A, Royston A, Rubin J, Russell G, Ryan F, Ryan N, Ryan S, Sabet A, Sabetypeyman F, Sachdev A, Saddik A, Sadhai R, Saeed S, Sahhar C, Saka M, Salauddin M, Salter E, Salter M, Samaddar A, Samarakkody A, Samararatna M, Samarsekera C, Samuel-John D, Sandars M, Sanders J, Sanderson L, Sandhu N, Sandrasegaram S, Sangsari A, Saprid J, Sarkis K, Sasse C, Satter F, Satyadharma K, Saul J, Scaife R, Schaap M, Scheelings FT, Schinckel H, Schlesinger P, Schlicht S, Schmidt M, Schneeweiss A, Schroeder E, Scully S, Searle R, Sebastian T, Seeto R, Segal G, Segal L, Seidel B, Selga A, Senanayake I, Seneviratne M, Seneviratne T, Senini D, Senior J, Seow L, Sepetavc D, Serafim A, Serban R, Sexton P, Shahat M, Shamoun Y, Shanmugarajah K, Shannon G, Sharif A, Shariff A, Sharma A, Sharma D, Sharma M, Sharma P, Sharma R, Sharma S, Sharma U, Sharp V, Sheen-Apostol J, Sheikh Mohamed M, Sher J, Sherley M, Shi B, Shimmin MB, Shing D, Shires SE, Shmerling A, Shortis P, Shroot AD, Shute J, Sia M, Siapantas S, Sidhwarni R, Siemienowicz J, Siew HC, Sigalov E, Silver D, Simes L, Simonson F, Simpson R, Simpson T, Simpson W, Singh B, Singh D, Singh H, Singh M, Singh R, Siow CL, Sitlington R, Sivapalan C, Skeat J, Skehan M, Skeklios L, Skinner T, Sklovsky CJ, Slabbert J, Slaney GM, Slattery C, Sleaby E, Sleiman C, Slesenger J, Slimming T, Sloan C, Sloane R, Slonim D, Slot P, Smagas T, Smart M, Smibert L, Smiley J, Smith D, Smith G, Smith J, Smith P, Smith R, Smith S, Smith S, Smith V, Smylie D, Sneyd S, Snow S, Sobol G, Soccio M, Solanki V, Soloczynskiyj A, Solomon D, Somerville M, Song J, Soo D, Soo L, Soo T, Soo TM, Sood R, Sooknandan S, Soon M, Sosnin M, Spanos N, Spargo JS, Speirs B, Spencer H, Spencer J, Spottiswood M, Spring M, Squires L, Stabelos G, Stagg M, Stanley L, Stark A, Steel A, Steer N, Steiner H, Stephanson A, Stephens G, Stephenson A, Sterling BR, Stevens B, Stevens P, Stevenson J, Stewart C, Stewart R, Sticklen E, Stiebel P, Stillger JM, Stinerman I, Stobie M, Stobie T, Stojkovski S, Stone A, Stowe S, Stoyanova V, Strasser K, Strong J, Struk H, Stuart A, Su J, Sujecki M, Suka R, Sullivan T, Sululola A, Sumathipala A, Suntesic L, Sutherland D, Sutherland I, Sutherland R, Sutton J, Swart R, Sweet M, Sweet R, Syed Z, Sykes J, Sylivris A, Symon B, Szabo R, Sze J, Szenczy C, Sze-Tho R, Szymanski I, Szymanski R, Tadrous M, Taft D, Taine M, Talic D, Tan E, Tan E, Tan G, Tan HM, Tanovic A, Tasiopoulos A, Tate K, Tattersall I, Taverna C, Taylor J, Taylor R, Taylor S, Teo K, Teoh C, Teperman B, Tereszkiewicz W, Thanenthiran R, Thangarajah C, Thangavel B, Thann Z, The S, Theophilos M, Theris N, Thiru K, Thiru M, Thomas G, Thomas P, Thompson D, Thompson L, Thompson W, Thomson B, Thorne A, Thornley J, Thorpe V, Thottakurichi R, Thurairajah A, Thurairajah S, Thyagarajan T, Tiet Q, Tillekeratne K, Tine S, Tinning R, Tinston C, To E, Tolentino C, Tom H, Tomar D, Tomic M, Tomyn L, Toohill G, Tooth M, Tormey S, Toua P, Trainor S, Tran C, Tran E, Tran LD, Tran TQ, Trethowan K, Trevena R, Trigg P, Trivett B, Try R, Tsigopoulos A, Tucker D, Tunaley S, Turnbull H, Turnbull S, Turner J, Twycross W, Tynan D, Tyndall P, Tyshing W, Uchendu F, Uhlenbruch B, Uluca U, Unkenstein D, Urie JP, Vaiopoulos T, Van Ammers E, Van Der Merwe D, Van Der Spek A, Van Der Vlist R, Van Opstal E, Vanderzeil G, Vanderzeil T, Vanker L, Vanmali H, Varghese A, Varney W, Vasquez I, Vasudevan S, Veal M, Venables S, Venkatram G, Verghese P, Verma H, Verma R, Verso M, Victor A, Vijayakumar V, Vijayanand P, Viljoen E, Vincent F, Vinci A, Vinci G, Viney P, Visvalingam C, Von Caemmerer A, Vonschmidt JK, Vorich R, Vrij R, Vyas S, Wai T, Waid S, Wakefield B, Walder D, Waldron CM, Waldron M, Wales S, Walker B, Walker G, Walker R, Walker W, Wall R, Wallace J, Wallace K, Wallis I, Wang S, Wang X, Wang Z, Ward C, Ward R, Ward S, Wardlaw P, Wark A, Warr A, Warren M, Waters L, Watson A, Watson S, Watt G, Watt J, Watterson J, Waugh R, Wazid M, Wearne E, Webb I, Webber C, Webber E, Webber S, Webster DL, Webster J, Webster P, Webster P, Weerasinghe S, Weerasoorya M, Weinrich J, Welberry L, Weller A, Wells S, Welsh D, Weng M, Wenig M, Wettesinghe I, Wexler P, White A, White G, White R, Whitehouse J, Whitehouse L, Whitehouse R, Whitfield K, Whitfield S, Whitney W, Wiehle G, Wight R, Wild I, Wilding S, Wildman G, Williams A, Williams G, Williams J, Williams M, Williams PD, Williams S, Williams W, Willis M, Wilson A, Win N, Wiseman J, Wishart W, Wivell F, Wong C, Wong CS, Wong D, Wong JK, Wong J, Wong JM, Wong P, Wong PT, Wong Y, Wood P, Woods R, Woodward P, Wooff D, Woolf S, Worboys P, Worboys PC, Wrennall R, Wright A, Wright A, Wright L, Wright R, Wright R, Wrobel K, Wu D, Wu E, Wu L, Xiao M, Yacoub M, Yang A, Yang J, Yang R, Yates D, Yazbek P, Yeaman C, Yeo M, Yeung Shi Chung D, Yiap D, Yilmaz S, Yogaranandan D, Young D, Young R, Young S, Yousef M, Yousif K, Youssef D, Yu Z, Yuille R, Zagorksi M, Zail S, Zain M, Zallmann A, Zeng L, Zhao S, Zhao W, Zheng M, Zhou D, Ziccone M, Zimmerman J, Zwijnenburg A.

Abstract

BACKGROUND:

Aspirin is a well-established therapy for the secondary prevention of cardiovascular events. However, its role in the primary prevention of cardiovascular disease is unclear, especially in older persons, who have an increased risk.

METHODS:

From 2010 through 2014, we enrolled community-dwelling men and women in Australia and the United States who were 70 years of age or older (or ≥65 years of age among blacks and Hispanics in the United States) and did not have cardiovascular disease, dementia, or disability. Participants were randomly assigned to receive 100 mg of enteric-coated aspirin or placebo. The primary end point was a composite of death, dementia, or persistent physical disability; results for this end point are reported in another article in the Journal. Secondary end points included major hemorrhage and cardiovascular disease (defined as fatal coronary heart disease, nonfatal myocardial infarction, fatal or nonfatal stroke, or hospitalization for heart failure).

RESULTS:

Of the 19,114 persons who were enrolled in the trial, 9525 were assigned to receive aspirin and 9589 to receive placebo. After a median of 4.7 years of follow-up, the rate of cardiovascular disease was 10.7 events per 1000 person-years in the aspirin group and 11.3 events per 1000 person-years in the placebo group (hazard ratio, 0.95; 95% confidence interval [CI], 0.83 to 1.08). The rate of major hemorrhage was 8.6 events per 1000 person-years and 6.2 events per 1000 person-years, respectively (hazard ratio, 1.38; 95% CI, 1.18 to 1.62; P<0.001).

CONCLUSIONS:

The use of low-dose aspirin as a primary prevention strategy in older adults resulted in a significantly higher risk of major hemorrhage and did not result in a significantly lower risk of cardiovascular disease than placebo. (Funded by the National Institute on Aging and others; ASPREE ClinicalTrials.gov number, NCT01038583 .).

PMID:
30221597
DOI:
10.1056/NEJMoa1805819

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center