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Expert Opin Drug Saf. 2018 Oct;17(10):983-989. doi: 10.1080/14740338.2018.1524460. Epub 2018 Sep 22.

Safety and efficacy of propofol anesthesia for pediatric target-controlled infusion in children below 3 years of age: a retrospective observational study.

Author information

1
a Department of Anesthesiology and Pain Medicine , Seoul National University Hospital , Seoul , Republic of Korea.
2
b Department of Anesthesiology and Pain Medicine, College of Medicine , Seoul National University , Seoul , Republic of Korea.

Abstract

BACKGROUND:

Although the requirement of propofol in children is increasing, propofol for induction and maintenance of anesthesia below 3 years old has not been approved in Korea. This study can provide a clinical evidence to increase the range of approval.

RESEARCH DESIGN AND METHODS:

We reviewed the medical records of patients below 3 years of age who underwent surgery between September 2013 and December 2016. Safety was evaluated on the basis of vital signs, and laboratory findings and efficacy were evaluated on the basis of the bispectral index (BIS). Adverse events were examined.

RESULTS:

A total of 109 patients anesthetized with propofol (propofol group) were compared with 109 patients with volatile anesthetics (volatile group) after propensity score matching. There was a difference in the proportion of patients showing decreased systolic pressure (P < 0.001) and heart rate (P = 0.03), but there was no difference in diastolic pressure (P = 0.238), mean arterial pressure (P = 0.175) during surgery. After surgery, there was no difference in all vital signs and the proportion patients who experienced adverse events of two groups.

CONCLUSIONS:

Propofol anesthesia by target-controlled infusion was effective and didn't show serious propofol-related perioperative adverse events.

KEYWORDS:

Pediatric anesthesia; propofol; target-controlled infusion; total intravenous anesthesia

PMID:
30221553
DOI:
10.1080/14740338.2018.1524460
[Indexed for MEDLINE]

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