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Urol J. 2018 Nov 17;15(6):365-369. doi: 10.22037/uj.v0i0.3716.

Is A Combination of Antibiotics and Non-Steroidal Anti-Inflammatory Drugs More Beneficial Than Antibiotic Monotherapy For The Treatment of Female Acute Uncomplicated Cystitis? A Randomized Controlled Pilot Study.

Author information

1
Department of Urology, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea. palindromes@hanmail.net.
2
Department of Urology, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Korea.
3
Department of Urology, Hallym University Hallym Sacred Heart Hospital, Gyeonggi, Korea.
4
Department of Urology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.
5
Department of Urology, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea.
6
Department of Urology, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea.

Abstract

 Purpose: To compare the efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) combination therapy to single-agent antibiotic therapy for the resolution of symptoms during two restricted activity days in patients with acute uncomplicated cystitis (AUC)Materials and Methods: We performed a prospective, randomized control pilot study. A total of 55 patients were enrolled. Group I (n=28) was treated with cepodoxime (100 mg twice per day), and Group II (n=27) was treated with cepodoxime (100 mg) and aceclofenac (100 mg) twice per day; both groups were treated for three days. Upon dysuria after each administration, the participants entered a value on a numerical pain scale. The primary outcome was whether there were any differences in the decrease rate in pain scale between the two groups.Result: The average age of the 55 patients was 49.9 ± 13.5 years, and prior to the clinical visit, the patients ex-perienced an average of 2.4 ± 2.2 days of dysuria symptoms. The average numerical pain scale score for dysuria was 4.98 ± 2.18. Thirty-four patients (61.8%) showed positive culture results, and E. coli was the most commonly found bacteria, cultured in 32 patients.Fifty-one patients visited the clinic on day 7, and 42 (76.4%) reported symptom improvement, while nine patients (16.3%) had persistent symptoms. The follow-up numerical pain score was 0.39 ± 1.02 points. The pain score was dramatically decreased after medication. No difference was observed in the magnitude of the pain scale reduction between the two groups (P = 0.134). However, group II showed faster symptom resolution (P = 0.035) at the third administration (day 1.5).Conclusion: Combination therapy with NSAIDs and antibiotics for AUC patients can improve symptoms faster during two restricted activity days when patients have difficulty performing daily living activities.

PMID:
30221336
DOI:
10.22037/uj.v0i0.3716
[Indexed for MEDLINE]
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