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Oncoimmunology. 2018 Mar 13;7(8):e1442169. doi: 10.1080/2162402X.2018.1442169. eCollection 2018.

Heating it up: Oncolytic viruses make tumors 'hot' and suitable for checkpoint blockade immunotherapies.

Gujar S1,2,3,4, Pol JG5,6,7,8,9, Kroemer G5,6,7,8,9,10,11,12.

Author information

1
Department of Pathology, Dalhousie University, Halifax, NS, Canada.
2
Department of Microbiology and Immunology, Dalhousie University, NS, Canada.
3
Department of Biology, Dalhousie University, NS, Canada.
4
Centre for Innovative and Collaborative Health Sciences Research, Quality and System Performance, IWK Health Centre, Halifax, NS, Canada.
5
Gustave Roussy Comprehensive Cancer Institute, Villejuif, France.
6
INSERM, Paris, France.
7
Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France.
8
Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France.
9
Université Pierre et Marie Curie/Paris VI, Paris, France.
10
Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France.
11
Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.
12
Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.

Abstract

Immune checkpoint blockade is less efficient in patients bearing immunologically 'cold' tumors. Oncolytic viruses, which were originally discovered for their ability to preferentially kill malignant cells, can recondition the tumor microenvironment. Supporting this hypothesis, two new studies published in Science Translational Medicine show that adjuvant-like activities of oncolytic viruses make brain and breast tumors 'hot' and sensitize them for subsequent immune checkpoint blockade.

KEYWORDS:

CTLA-4; Immunosurveillance; Inflammation and cancer; PD-1; PD-L1; antibodies; antitumor response; antiviral response; immune checkpoint; immunosurveillance; immunotherapy; models of immunostimulation; oncolytic virus; therapeutic antibodies

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