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J Family Community Med. 2018 Sep-Dec;25(3):183-187. doi: 10.4103/jfcm.JFCM_153_17.

Pediatric sickle cell disease and obstructive sleep apnea: A cross-sectional study in a tertiary pediatric center in Saudi Arabia.

Author information

1
Department of Pediatrics, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.
2
Department of Hematology Oncology, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.
3
Sleep disorders Center, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.
4
Division of Respiratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.
5
Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.

Abstract

OBJECTIVE:

The aim of the study was to evaluate snoring and obstructive sleep apnea (OSA) in Saudi children with sickle cell disease (SCD).

MATERIALS AND METHODS:

This cross-sectional study was conducted among children with SCD attending a hematology clinic were recruited. Demographics, clinical data, and sleep questionnaires were collected and overnight polysomnographies performed.

RESULTS:

Seventy children (31 of whom were females) with SCD were included in the study. Their median (interquartile) age was 9 (6.5, 11) years and their body mass index z-score was -1.2 (-2.0, -0.4). Seventy-four percent of SCD patients snored and 32 (46%) had evidence of OSA (obstructive apnea-hypopnea index [OAHI] ≥2 events per hour of sleep), 13 of whom had moderate OSA (OAHI ≥5 and <10 events per hour of sleep) and 10 had severe OSA (OAHI ≥10 events per hour of sleep).

CONCLUSION:

Snoring and the proportion of OSA were high in children with SCD. This underlines the importance of screening for OSA in all children with SCD.

KEYWORDS:

Obstructive sleep apnea; pediatrics; sickle cell disease

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