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BMC Public Health. 2018 Sep 15;18(1):1124. doi: 10.1186/s12889-018-6009-1.

Effects of alternate day calorie restriction and exercise on cardio-metabolic risk factors in overweight and obese adults: an exploratory randomized controlled study.

Oh M1, Kim S2, An KY3, Min J4,5, Yang HI4,5, Lee J6, Lee MK4,5, Kim DI7, Lee HS8, Lee JW9, Jeon JY10,11.

Author information

1
Department of Health and Human Physiology, University of Iowa, Iowa City, IA, USA.
2
Department of Family Medicine, Severance Hospital, Yonsei University, College of Medicine, Seoul, South Korea.
3
Faculty of Physical Education and Recreation, University of Alberta, Edmonton, AB, Canada.
4
Department of Sport and Leisure Studies, Yonsei University, Seoul, South Korea.
5
Exercise Medicine Center for Cancer and Diabetes Patients, ICONS, Yonsei University, Seoul, South Korea.
6
Graduate School of Sport Science, Kyung Hee University, Yongin-Si, South Korea.
7
Department of Professional Therapy, Graduate School of Professional Therapy, Gachon University, Geonggi-do, South Korea.
8
Department of Biostatistics, Yonsei University, College of Medicine, Seoul, South Korea.
9
Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. INDI5645@yuhs.ac.
10
Department of Sport and Leisure Studies, Yonsei University, Seoul, South Korea. jjeon@yonsei.ac.kr.
11
Exercise Medicine Center for Cancer and Diabetes Patients, ICONS, Yonsei University, Seoul, South Korea. jjeon@yonsei.ac.kr.

Abstract

BACKGROUND:

It has been recognized that alternate day calorie restriction (ADCR) or exercise has positive effects on cardio-metabolic risk factors. It is unclear whether the combined effect of ADCR and exercise (aerobic + resistance training) influences risk. We investigated effects of an 8-week ADCR and exercise program (aerobic + resistance training) on cardio-metabolic risk factors in overweight and obese adults.

METHODS:

This study randomized 45 overweight or obese but healthy adults (F = 26, M = 19; aged about 32 to 40 years) into 4 groups: ADCR (n = 13), exercise (n = 10), exercise plus ADCR (n = 12), and control (n = 10) for 8 weeks. Body composition, blood lipids profile, and insulin resistance were measured. The intention to treat (ITT) method was used to analyze all participants that were randomized.

RESULTS:

A total of 35 participants completed the trial (78%). Body weight, body mass index, waist circumference, fat mass and percent body fat were reduced in the exercise plus ADCR group (- 3.3 ± 2.4 kg, p < 0.01; - 1.3 ± 1.0 kg/m2, p < 0.01; - 4.1 ± 3.9 cm, p < 0.01; - 2.7 ± 2.0 kg, p < 0.01; - 2. 5 ± 2.2%, p < 0.01). Insulin, glucose, homeostasis model assessment insulin resistance and triglyceride (- 2.9 ± 4.1 μIU/ml, p < 0.05; - 10.9 ± 16.9 mg/dl, p < 0.05; - 0.9 ± 1.3, p < 0.05; - 43.8 ± 41.9 mg/dl, p < 0.01) decreased in the exercise plus ADCR group only.

CONCLUSIONS:

ADCR and exercise both proved to be beneficial, but the combined intervention was most effective at inducing beneficial changes in body weight, body composition, glucose, insulin, insulin resistance and triglyceride in overweight and obese adults.

TRIAL REGISTRATION:

ClinicalTrials.gov: NCT03652532 , Registered August 28, 2018, 'retrospectively registered'.

KEYWORDS:

Alternate day calorie restriction; Body weight; Exercise; Insulin resistance; Obesity

PMID:
30219052
PMCID:
PMC6139127
DOI:
10.1186/s12889-018-6009-1
[Indexed for MEDLINE]
Free PMC Article

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