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Eur Biophys J. 2018 Sep 14. doi: 10.1007/s00249-018-1333-z. [Epub ahead of print]

Analytical ultracentrifugation (AUC): a seminal tool offering multiple solutions.

Author information

1
School of Life Sciences, University of Glasgow, Sir Graeme Davies Building, 120 University Place, Glasgow, G12 8TA, UK. olwyn.byron@glasgow.ac.uk.
2
Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstra├če 10, 07743, Jena, Germany.
3
Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743, Jena, Germany.
4
Department of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada.

Abstract

Analytical ultracentrifugation (AUC) remains a highly versatile and widely applicable tool for the analysis of macromolecules and their interactions. The current state-of-the-art was demonstrated at a recent international meeting held in Glasgow, Scotland, in July 2017, the 23rd International Analytical Ultracentrifugation Workshop and Symposium. This special issue showcases the reports made at the meeting, which concerned the application of AUC to a wide range of topics in biochemical and polymer science including antibody and membrane protein characterisation, and protein-carbohydrate interactions. Presentations on development and testing of new instrumentation and methods of analysis were a particular feature of the meeting, including the optimisation of experimental protocols, and the latest optimised computational approaches to experimental simulation and the modelling of macromolecular structures.

PMID:
30218114
DOI:
10.1007/s00249-018-1333-z

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