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Int J Mol Sci. 2018 Sep 13;19(9). pii: E2736. doi: 10.3390/ijms19092736.

The Anti-Inflammatory Effects of Vitamin D in Tumorigenesis.

Liu W1,2, Zhang L3,4, Xu HJ5,6, Li Y7,8, Hu CM9, Yang JY10, Sun MY11,12.

Author information

1
College of Laboratory Medicine, Jilin Medical University, Jilin 132013, China. liuweijldx@sina.com.
2
Laboratory of Antibody Engineering, Jilin Medical University, Jilin 132013, China. liuweijldx@sina.com.
3
College of Laboratory Medicine, Jilin Medical University, Jilin 132013, China. zhanglei0358@sina.com.
4
Laboratory of Antibody Engineering, Jilin Medical University, Jilin 132013, China. zhanglei0358@sina.com.
5
College of Laboratory Medicine, Jilin Medical University, Jilin 132013, China. renyunqingzheng@126.com.
6
Laboratory of Antibody Engineering, Jilin Medical University, Jilin 132013, China. renyunqingzheng@126.com.
7
College of Laboratory Medicine, Jilin Medical University, Jilin 132013, China. jlliyang2004@163.com.
8
Laboratory of Antibody Engineering, Jilin Medical University, Jilin 132013, China. jlliyang2004@163.com.
9
Laboratory of Antibody Engineering, Jilin Medical University, Jilin 132013, China. chuminhu@163.com.
10
Department of Physical Education, Jilin Medical University, Jilin 132013, China. yjy8899@126.com.
11
College of Laboratory Medicine, Jilin Medical University, Jilin 132013, China. sunmy990@163.com.
12
Laboratory of Antibody Engineering, Jilin Medical University, Jilin 132013, China. sunmy990@163.com.

Abstract

In conjunction with the classical functions of regulating intestinal, bone, and kidney calcium and phosphorus absorption, as well as bone mineralization of vitamin D, the population-based association between low vitamin D status and increased cancer risk is now generally accepted. Inflammation is causally related to oncogenesis. It is widely thought that vitamin D plays an important role in the modulation of the inflammation system by regulating the production of inflammatory cytokines and immune cells, which are crucial for the pathogenesis of many immune-related diseases. Mechanistic studies have shown that vitamin D influences inflammatory processes involved in cancer progression, including cytokines, prostaglandins, MAP kinase phosphatase 5 (MKP5), the nuclear factor kappa B (NF-κB) pathway, and immune cells. Multiple studies have shown that vitamin D has the potential to inhibit tumor development by interfering with the inflammation system. The present review summarizes recent studies of the mechanisms of vitamin D on regulating the inflammation system, which contributes to its potential for cancer prevention and therapy. This review helps answer whether inflammation mediates a causal relationship between vitamin D and tumorigenesis.

KEYWORDS:

cytokines; immune cells; inflammation; tumorigenesis; vitamin D

PMID:
30216977
PMCID:
PMC6164284
DOI:
10.3390/ijms19092736
[Indexed for MEDLINE]
Free PMC Article

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