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Prostate Cancer Prostatic Dis. 2019 Mar;22(1):77-83. doi: 10.1038/s41391-018-0090-5. Epub 2018 Sep 13.

Nocturia and associated mortality: observational data from the REDUCE trial.

Author information

1
Emory University School of Medicine, Atlanta, GA, USA. dbliwis@emory.edu.
2
Duke University School of Medicine, Durham, NC, USA.
3
University of Illinois at Chicago, Chicago, IL, USA.
4
Washington University School of Medicine, St. Louis, MO, USA.
5
Cedars-Sinai Medical Center, Los Angeles, CA, USA.
6
Durham Veterans Affairs Medical Center, Durham, NC, USA.

Abstract

BACKGROUND:

Nocturia (voids arising from sleep) is a ubiquitous phenomenon reflecting many diverse conditions but whether it has significance in its own right remains uncertain. We examined whether nocturia was an independent risk factor for mortality METHODS: These were observational analyses employing primarily North American and European participants and included 7343 men, aged 50-75 years participating in the REDUCE (Reduction by Dutasteride of Prostate Cancer Events) trial. Cox proportional hazards models were used to test the association between baseline nocturia (voiding ≥3 times per night) and all-cause mortality. Potential confounding variables included: age; race; region of origin; treatment group; self-reported coronary artery disease, diabetes mellitus, hypertension, and peripheral vascular disease; smoking; alcohol use; prostate volume; and diuretics. Self-reported sleep quality, as measured with the Medical Outcomes Study sleep scale, was entered as a final step in the model.

RESULTS:

Nocturia was associated with increased mortality risk (hazard ratio [HR] = 1.72; 95% CI 1.15-2.55) independent from demographics and medical comorbidities. Inclusion of disturbed sleep in the model reduced the magnitude of the association (HR = 1.43; 95% CI 0.93-2.19).

CONCLUSIONS:

Although the findings are limited to men, half of whom ingested dutasteride, the interruption of sleep by nocturia may have long-term impact on health and may warrant targeted intervention.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00056407.

Comment in

PMID:
30214036
DOI:
10.1038/s41391-018-0090-5
[Indexed for MEDLINE]

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