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Sci Rep. 2018 Sep 13;8(1):13747. doi: 10.1038/s41598-018-32146-2.

A comprehensive manually-curated compendium of bovine transcription factors.

Author information

1
Post-graduation Program of Evolutionary Genetics and Molecular Biology, Federal University of São Carlos, São Carlos, São Paulo, 13560-970, Brazil.
2
Animal Biotechnology, Embrapa Pecuária Sudeste, São Carlos, São Paulo, 13560-970, Brazil.
3
Bioinformatic Multi-user Laboratory, Embrapa Informática Agropecuária, Campinas, São Paulo, 70770-901, Brazil.
4
NGS Genomic Solutions, Piracicaba, São Paulo, Brazil.
5
Division of Animal Science, University of Missouri, Columbia, Missouri, 65211-5300, USA.
6
Functional Genomic Center, University of São Paulo, Piracicaba, São Paulo, 13418-900, Brazil.
7
Animal Biotechnology, Embrapa Pecuária Sudeste, São Carlos, São Paulo, 13560-970, Brazil. luciana.regitano@embrapa.br.

Abstract

Transcription factors (TFs) are pivotal regulatory proteins that control gene expression in a context-dependent and tissue-specific manner. In contrast to human, where comprehensive curated TF collections exist, bovine TFs are only rudimentary recorded and characterized. In this article, we present a manually-curated compendium of 865 sequence-specific DNA-binding bovines TFs, which we analyzed for domain family distribution, evolutionary conservation, and tissue-specific expression. In addition, we provide a list of putative transcription cofactors derived from known interactions with the identified TFs. Since there is a general lack of knowledge concerning the regulation of gene expression in cattle, the curated list of TF should provide a basis for an improved comprehension of regulatory mechanisms that are specific to the species.

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