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J Am Coll Cardiol. 2018 Sep 18;72(12):1397-1416. doi: 10.1016/j.jacc.2018.06.063.

Rheumatic Heart Disease Worldwide: JACC Scientific Expert Panel.

Author information

1
Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, Washington; Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa; Department of Paediatrics, University of Cape Town and Red Cross War Memorial Children's Hospital, Cape Town, South Africa. Electronic address: davidaw@uw.edu.
2
Children's National Health System, Washington, DC.
3
Telethon Kids Institute, University of Western Australia, Subiaco, Western Australia, Australia; Princess Margaret Hospital for Children, Perth, Western Australia, Australia.
4
Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.
5
Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa; The Deans Suite, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
6
Telethon Kids Institute, University of Western Australia, Subiaco, Western Australia, Australia; Office of the Chief Scientist, The George Institute for Global Health, UNSW Sydney, Camperdown, New South Wales, Australia.
7
Aswan Heart Centre, Aswan, Egypt.
8
Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa; Department of Paediatrics, University of Cape Town and Red Cross War Memorial Children's Hospital, Cape Town, South Africa.

Abstract

Rheumatic heart disease (RHD) is a preventable heart condition that remains endemic among vulnerable groups in many countries. After a period of relative neglect, there has been a resurging interest in RHD worldwide over the past decade. In this Scientific Expert Panel, the authors summarize recent advances in the science of RHD and sketch out priorities for current action and future research. Key questions for laboratory research into disease pathogenesis and epidemiological research on the burden of disease are identified. The authors present a variety of pressing clinical research questions on optimal RHD prevention and advanced care. In addition, they propose a policy and implementation research agenda that can help translate current evidence into tangible action. The authors maintain that, despite knowledge gaps, there is sufficient evidence for national and global action on RHD, and they argue that RHD is a model for strengthening health systems to address other cardiovascular diseases in limited-resource countries.

KEYWORDS:

cardiac surgery; echocardiography; health services; pathogenesis; prevention; rheumatic heart disease

PMID:
30213333
DOI:
10.1016/j.jacc.2018.06.063

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